Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women.
PROBLEM: We investigated leukocyte and lymphocyte subsets in HIV-infected or HIV-uninfected, pregnant or non-pregnant Malawian women to explore whether HIV infection and pregnancy may act synergistically to impair cellular immunity. METHOD OF STUDY: We recruited 54 pregnant and 48 non-pregnant HIV-u...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Wiley
2017
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| _version_ | 1826304605223387136 |
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| author | Mandala, W Gondwe, E Molyneux, M MacLennan, J MacLennan, C |
| author_facet | Mandala, W Gondwe, E Molyneux, M MacLennan, J MacLennan, C |
| author_sort | Mandala, W |
| collection | OXFORD |
| description | PROBLEM: We investigated leukocyte and lymphocyte subsets in HIV-infected or HIV-uninfected, pregnant or non-pregnant Malawian women to explore whether HIV infection and pregnancy may act synergistically to impair cellular immunity. METHOD OF STUDY: We recruited 54 pregnant and 48 non-pregnant HIV-uninfected women and 24 pregnant and 20 non-pregnant HIV-infected Malawian women. We compared peripheral blood leukocyte and lymphocyte subsets between women in the four groups. RESULTS: Parturient HIV-infected and HIV-uninfected women had more neutrophils (each P<.0001), but fewer lymphocytes (P<.0001; P=.0014) than non-pregnant women. Both groups had fewer total T cells (P<.0001; P=.002) and CD8(+) T cells (P<.0001; P=.014) than non-pregnant women. HIV-uninfected parturient women had fewer CD4(+) and γδ T cells, B and NK cells (each P<.0001) than non-pregnant women. Lymphocyte subset percentages were not affected by pregnancy. CONCLUSION: Malawian women at parturition have an increased total white cell count due to neutrophilia and an HIV-unrelated pan-lymphopenia. |
| first_indexed | 2024-03-07T06:20:22Z |
| format | Journal article |
| id | oxford-uuid:f282fb7c-1dbe-45ce-9e90-c328e7218ddd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:20:22Z |
| publishDate | 2017 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:f282fb7c-1dbe-45ce-9e90-c328e7218ddd2022-03-27T12:04:27ZLeukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f282fb7c-1dbe-45ce-9e90-c328e7218dddEnglishSymplectic Elements at OxfordWiley2017Mandala, WGondwe, EMolyneux, MMacLennan, JMacLennan, CPROBLEM: We investigated leukocyte and lymphocyte subsets in HIV-infected or HIV-uninfected, pregnant or non-pregnant Malawian women to explore whether HIV infection and pregnancy may act synergistically to impair cellular immunity. METHOD OF STUDY: We recruited 54 pregnant and 48 non-pregnant HIV-uninfected women and 24 pregnant and 20 non-pregnant HIV-infected Malawian women. We compared peripheral blood leukocyte and lymphocyte subsets between women in the four groups. RESULTS: Parturient HIV-infected and HIV-uninfected women had more neutrophils (each P<.0001), but fewer lymphocytes (P<.0001; P=.0014) than non-pregnant women. Both groups had fewer total T cells (P<.0001; P=.002) and CD8(+) T cells (P<.0001; P=.014) than non-pregnant women. HIV-uninfected parturient women had fewer CD4(+) and γδ T cells, B and NK cells (each P<.0001) than non-pregnant women. Lymphocyte subset percentages were not affected by pregnancy. CONCLUSION: Malawian women at parturition have an increased total white cell count due to neutrophilia and an HIV-unrelated pan-lymphopenia. |
| spellingShingle | Mandala, W Gondwe, E Molyneux, M MacLennan, J MacLennan, C Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women. |
| title | Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women. |
| title_full | Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women. |
| title_fullStr | Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women. |
| title_full_unstemmed | Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women. |
| title_short | Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women. |
| title_sort | leukocyte counts and lymphocyte subsets in relation to pregnancy and hiv infection in malawian women |
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