Maintenance of basal plasma glucose and insulin concentrations in maturity-onset diabetes.
Normal and mildly diabetic subjects each have their own "set" of basal plasma glucose and insulin concentrations. Diabetic patients have raised basal plasma glucose, with low-normal basal plasma C-peptide concentrations. Restoring normal glucose levels in mild diabetes by an insulin infusi...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1979
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| _version_ | 1797103466978476032 |
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| author | Holman, R Turner, R |
| author_facet | Holman, R Turner, R |
| author_sort | Holman, R |
| collection | OXFORD |
| description | Normal and mildly diabetic subjects each have their own "set" of basal plasma glucose and insulin concentrations. Diabetic patients have raised basal plasma glucose, with low-normal basal plasma C-peptide concentrations. Restoring normal glucose levels in mild diabetes by an insulin infusion further reduces the C-peptide concentration, but both the plasma glucose and the C-peptide return to their "set" level when the insulin is withdrawn. These results accord with the action of beta cells and liver in a negative feedback loop that maintains basal plasma glucose and insulin concentrations. |
| first_indexed | 2024-03-07T06:20:32Z |
| format | Journal article |
| id | oxford-uuid:f28f30d8-74bf-4c14-b5a8-7d933419415d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:20:32Z |
| publishDate | 1979 |
| record_format | dspace |
| spelling | oxford-uuid:f28f30d8-74bf-4c14-b5a8-7d933419415d2022-03-27T12:04:49ZMaintenance of basal plasma glucose and insulin concentrations in maturity-onset diabetes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f28f30d8-74bf-4c14-b5a8-7d933419415dEnglishSymplectic Elements at Oxford1979Holman, RTurner, RNormal and mildly diabetic subjects each have their own "set" of basal plasma glucose and insulin concentrations. Diabetic patients have raised basal plasma glucose, with low-normal basal plasma C-peptide concentrations. Restoring normal glucose levels in mild diabetes by an insulin infusion further reduces the C-peptide concentration, but both the plasma glucose and the C-peptide return to their "set" level when the insulin is withdrawn. These results accord with the action of beta cells and liver in a negative feedback loop that maintains basal plasma glucose and insulin concentrations. |
| spellingShingle | Holman, R Turner, R Maintenance of basal plasma glucose and insulin concentrations in maturity-onset diabetes. |
| title | Maintenance of basal plasma glucose and insulin concentrations in maturity-onset diabetes. |
| title_full | Maintenance of basal plasma glucose and insulin concentrations in maturity-onset diabetes. |
| title_fullStr | Maintenance of basal plasma glucose and insulin concentrations in maturity-onset diabetes. |
| title_full_unstemmed | Maintenance of basal plasma glucose and insulin concentrations in maturity-onset diabetes. |
| title_short | Maintenance of basal plasma glucose and insulin concentrations in maturity-onset diabetes. |
| title_sort | maintenance of basal plasma glucose and insulin concentrations in maturity onset diabetes |
| work_keys_str_mv | AT holmanr maintenanceofbasalplasmaglucoseandinsulinconcentrationsinmaturityonsetdiabetes AT turnerr maintenanceofbasalplasmaglucoseandinsulinconcentrationsinmaturityonsetdiabetes |