The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode.

The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode.

Shikimate dehydrogenase catalyzes the NADPH-dependent reversible reduction of 3-dehydroshikimate to shikimate. We report the first X-ray structure of shikimate dehydrogenase from Haemophilus influenzae to 2.4-A resolution and its complex with NADPH to 1.95-A resolution. The molecule contains two dom...

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Bibliographic Details
Main Authors:	Ye, S, von Delft, F, Brooun, A, Knuth, M, Swanson, R, McRee, D
Format:	Journal article
Language:	English
Published:	2003

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