The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity.

The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity.

Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate severe dengue by promoting heterotypic virus entry via Fcγ receptors (FcγR). We immortalized memory B cells from individuals after primary or secondary infection and analyzed anti-DENV monoclonal antibodies (mAbs...

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Main Authors: Beltramello, M, Williams, K, Simmons, C, Macagno, A, Simonelli, L, Quyen, N, Sukupolvi-Petty, S, Navarro-Sanchez, E, Young, P, de Silva, A, Rey, F, Varani, L, Whitehead, S, Diamond, MS, Harris, E, Lanzavecchia, A, Sallusto, F
Format: Journal article
Language:English
Published: 2010

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