Identification of two distinct pathways of human myelopoiesis
Human myelopoiesis has been proposed to occur through oligopotent common myeloid progenitor (CMP) and lymphoid-primed multipotent progenitor (LMPP) populations. However, other studies have proposed direct commitment of multipotent cells to unilineage fates, without specific intermediary lineage cose...
| Main Authors: | , , , |
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| Format: | Journal article |
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American Association for the Advancement of Science
2019
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| _version_ | 1797103523284910080 |
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| author | Drissen, R Thongjuea, S Theilgaard-Mönch, K Nerlov, C |
| author_facet | Drissen, R Thongjuea, S Theilgaard-Mönch, K Nerlov, C |
| author_sort | Drissen, R |
| collection | OXFORD |
| description | Human myelopoiesis has been proposed to occur through oligopotent common myeloid progenitor (CMP) and lymphoid-primed multipotent progenitor (LMPP) populations. However, other studies have proposed direct commitment of multipotent cells to unilineage fates, without specific intermediary lineage cosegregation patterns. We here show that distinct human myeloid progenitor populations generate the neutrophil/monocyte and mast cell/basophil/eosinophil lineages as previously shown in mouse. Moreover, we find that neutrophil/monocyte potential selectively cosegregates with lymphoid lineage and mast cell/basophil/eosinophil potentials with megakaryocyte/erythroid potential early during lineage commitment. Furthermore, after this initial commitment step, mast cell/basophil/eosinophil and megakaryocyte/erythroid potentials colocalize at the single-cell level in restricted oligopotent progenitors. These results show that human myeloid lineages are generated through two distinct cellular pathways defined by complementary oligopotent cell populations. |
| first_indexed | 2024-03-07T06:21:17Z |
| format | Journal article |
| id | oxford-uuid:f2cb7cd6-1b05-4a8d-8b96-e0ada7375808 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T06:21:17Z |
| publishDate | 2019 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:f2cb7cd6-1b05-4a8d-8b96-e0ada73758082022-03-27T12:06:51ZIdentification of two distinct pathways of human myelopoiesisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f2cb7cd6-1b05-4a8d-8b96-e0ada7375808Symplectic Elements at OxfordAmerican Association for the Advancement of Science2019Drissen, RThongjuea, STheilgaard-Mönch, KNerlov, CHuman myelopoiesis has been proposed to occur through oligopotent common myeloid progenitor (CMP) and lymphoid-primed multipotent progenitor (LMPP) populations. However, other studies have proposed direct commitment of multipotent cells to unilineage fates, without specific intermediary lineage cosegregation patterns. We here show that distinct human myeloid progenitor populations generate the neutrophil/monocyte and mast cell/basophil/eosinophil lineages as previously shown in mouse. Moreover, we find that neutrophil/monocyte potential selectively cosegregates with lymphoid lineage and mast cell/basophil/eosinophil potentials with megakaryocyte/erythroid potential early during lineage commitment. Furthermore, after this initial commitment step, mast cell/basophil/eosinophil and megakaryocyte/erythroid potentials colocalize at the single-cell level in restricted oligopotent progenitors. These results show that human myeloid lineages are generated through two distinct cellular pathways defined by complementary oligopotent cell populations. |
| spellingShingle | Drissen, R Thongjuea, S Theilgaard-Mönch, K Nerlov, C Identification of two distinct pathways of human myelopoiesis |
| title | Identification of two distinct pathways of human myelopoiesis |
| title_full | Identification of two distinct pathways of human myelopoiesis |
| title_fullStr | Identification of two distinct pathways of human myelopoiesis |
| title_full_unstemmed | Identification of two distinct pathways of human myelopoiesis |
| title_short | Identification of two distinct pathways of human myelopoiesis |
| title_sort | identification of two distinct pathways of human myelopoiesis |
| work_keys_str_mv | AT drissenr identificationoftwodistinctpathwaysofhumanmyelopoiesis AT thongjueas identificationoftwodistinctpathwaysofhumanmyelopoiesis AT theilgaardmonchk identificationoftwodistinctpathwaysofhumanmyelopoiesis AT nerlovc identificationoftwodistinctpathwaysofhumanmyelopoiesis |