Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H.
We report a patient with peripheral rheumatoid corneal melting who developed a corneal perforation in one eye requiring tectonic keratoplasty. Nine consecutive corneal grafts were rapidly destroyed despite systemic immunosuppression with corticosteroid, cyclophosphamide, azathioprine and cyclosporin...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1995
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| _version_ | 1797103525319147520 |
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| author | Newman, D Isaacs, J Watson, P Meyer, P Hale, G Waldmann, H |
| author_facet | Newman, D Isaacs, J Watson, P Meyer, P Hale, G Waldmann, H |
| author_sort | Newman, D |
| collection | OXFORD |
| description | We report a patient with peripheral rheumatoid corneal melting who developed a corneal perforation in one eye requiring tectonic keratoplasty. Nine consecutive corneal grafts were rapidly destroyed despite systemic immunosuppression with corticosteroid, cyclophosphamide, azathioprine and cyclosporin A. A rejection episode was observed in one graft before it melted and allograft rejection may have contributed to the destruction of other grafts. Corneal graft survival was ultimately achieved by systemic immunosuppression with the anti-lymphocyte monoclonal antibody, CAMPATH-1H. A single episode of rejection developed in the early post-operative period which was easily reversed by topical corticosteroid. Corneal melting has not recurred and the graft has now remained intact and clear for 24 months. Anti-lymphocyte monoclonal antibodies may therefore provide effective immunosuppression in the treatment of refractory ocular disorders. |
| first_indexed | 2024-03-07T06:21:19Z |
| format | Journal article |
| id | oxford-uuid:f2cdabb2-a4ee-45f6-bc81-585227bf009c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:21:19Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:f2cdabb2-a4ee-45f6-bc81-585227bf009c2022-03-27T12:06:50ZPrevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f2cdabb2-a4ee-45f6-bc81-585227bf009cEnglishSymplectic Elements at Oxford1995Newman, DIsaacs, JWatson, PMeyer, PHale, GWaldmann, HWe report a patient with peripheral rheumatoid corneal melting who developed a corneal perforation in one eye requiring tectonic keratoplasty. Nine consecutive corneal grafts were rapidly destroyed despite systemic immunosuppression with corticosteroid, cyclophosphamide, azathioprine and cyclosporin A. A rejection episode was observed in one graft before it melted and allograft rejection may have contributed to the destruction of other grafts. Corneal graft survival was ultimately achieved by systemic immunosuppression with the anti-lymphocyte monoclonal antibody, CAMPATH-1H. A single episode of rejection developed in the early post-operative period which was easily reversed by topical corticosteroid. Corneal melting has not recurred and the graft has now remained intact and clear for 24 months. Anti-lymphocyte monoclonal antibodies may therefore provide effective immunosuppression in the treatment of refractory ocular disorders. |
| spellingShingle | Newman, D Isaacs, J Watson, P Meyer, P Hale, G Waldmann, H Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H. |
| title | Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H. |
| title_full | Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H. |
| title_fullStr | Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H. |
| title_full_unstemmed | Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H. |
| title_short | Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H. |
| title_sort | prevention of immune mediated corneal graft destruction with the anti lymphocyte monoclonal antibody campath 1h |
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