Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H.

Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H.

We report a patient with peripheral rheumatoid corneal melting who developed a corneal perforation in one eye requiring tectonic keratoplasty. Nine consecutive corneal grafts were rapidly destroyed despite systemic immunosuppression with corticosteroid, cyclophosphamide, azathioprine and cyclosporin...

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Bibliografiska uppgifter
Huvudupphovsmän:	Newman, D, Isaacs, J, Watson, P, Meyer, P, Hale, G, Waldmann, H
Materialtyp:	Journal article
Språk:	English
Publicerad:	1995

Liknande verk

Monoclonal antibody therapy of chronic intraocular inflammation using Campath-1H.
av: Isaacs, J, et al.
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Specificity of monoclonal antibody Campath-1.
av: Hale, G, et al.
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CAMPATH-1 monoclonal antibodies in bone marrow transplantation.
av: Hale, G, et al.
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Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1).
av: Waldmann, H, et al.
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Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H.
av: Isaacs, J, et al.
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Anti-globulin responses to rat and humanized CAMPATH-1 monoclonal antibody used to treat transplant rejection.
av: Rebello, P, et al.
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EFFECTS OF MONOCLONAL-ANTIBODIES OF THE CAMPATH SERIES INVIVO - REQUIREMENTS FOR EFFECTIVE ANTIBODY THERAPY
av: Dyer, M, et al.
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Rat monoclonal antibodies for bone marrow transplantation--the CAMPATH series.
av: Waldmann, H, et al.
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Reversal of allograft rejection using the monoclonal antibody, Campath-1G.
av: Friend, P, et al.
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RAT MONOCLONAL-ANTIBODIES FOR BONE-MARROW TRANSPLANTATION (BMT) - THE CAMPATH SERIES
av: Waldmann, H, et al.
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CAMPATH-1 monoclonal antibody therapy in severe refractory autoimmune thrombocytopenic purpura.
av: Lim, S, et al.
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Recent results using CAMPATH-1 antibodies to control GVHD and graft rejection.
av: Hale, G, et al.
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REMISSION INDUCTION IN PATIENTS WITH LYMPHOID MALIGNANCIES USING UNCONJUGATED CAMPATH-1 MONOCLONAL-ANTIBODIES
av: Dyer, M, et al.
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Engraftment of marrow allografts treated with Campath-1 monoclonal antibodies.
av: Naparstek, E, et al.
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ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR LEUKEMIA USING CAMPATH-1 MONOCLONAL-ANTIBODIES AND POSTTRANSPLANT ALLOIMMUNIZATION WITH DONOR LYMPHOCYTES
av: Naparstek, E, et al.
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Pilot study of CAMPATH-1, a rat monoclonal antibody that fixes human complement, as an immunosuppressant in organ transplantation.
av: Hale, G, et al.
Publicerad: (1986)

TREATMENT OF RHEUMATOID-ARTHRITIS WITH HUMANIZED ANTILYMPHOCYTE ANTIBODY CAMPATH-1H
av: Watts, R, et al.
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Availability of Campath-1 antibodies for bone marrow transplantation.
av: Hale, G, et al.
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Delayed allograft rejection in primates treated with anti-IL-2 receptor monoclonal antibody Campath-6.
av: Tighe, H, et al.
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Impact on T-cell depletion and CD34+ cell recovery using humanised CD52 monoclonal antibody (CAMPATH-1H) in BM and PSBC collections; comparison with CAMPATH-1M and CAMPATH-1G.
av: Williams, R, et al.
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Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H.
av: Hale, G, et al.
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CAMPATH-1H in inflammatory arthritis.
av: Watts, R, et al.
Publicerad: (1993)

Campath-1H therapy in refractory ocular inflammatory disease.
av: Dick, A, et al.
Publicerad: (2000)

Direct antibody rosette-forming reactions using monoclonal markers of lymphocyte subpopulations. Methodology and applications illustrated by investigations with rat pan-T antibodies of the CAMPATH series.
av: Wilson, AB, et al.
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T-CELL DEPLETION BY EXPOSURE TO CAMPATH-1G IN-VITRO PREVENTS GRAFT-VERSUS-HOST DISEASE
av: Jacobs, P, et al.
Publicerad: (1994)

Reactivity of rat monoclonal antibody CAMPATH-1 with human leukaemia cells and its possible application for autologous bone marrow transplantation.
av: Hale, G, et al.
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Control of graft-versus-host disease and graft rejection by T cell depletion of donor and recipient with Campath-1 antibodies. Results of matched sibling transplants for malignant diseases.
av: Hale, G, et al.
Publicerad: (1994)

CAMPATH-1 FOR PREVENTION OF GRAFT-VERSUS-HOST DISEASE AND GRAFT-REJECTION - SUMMARY OF RESULTS FROM A MULTI-CENTRE STUDY
av: Hale, G, et al.
Publicerad: (1988)

CAMPATH: from concept to clinic.
av: Waldmann, H, et al.
Publicerad: (2005)

Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL).
av: Lundin, J, et al.
Publicerad: (2002)

Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation.
av: Heit, W, et al.
Publicerad: (1986)

ISOTYPE VARIANTS OF CAMPATH-1 ANTIBODY - REQUIREMENTS FOR EFFECTIVE ANTIBODY ACTION INVIVO
av: Dyer, M, et al.
Publicerad: (1989)

T cell depletion by exposure to Campath-1G in vitro prevents graft-versus-host disease.
av: Jacobs, P, et al.
Publicerad: (1994)

CAMPATH-1 antibodies in stem-cell transplantation.
av: Hale, G, et al.
Publicerad: (2001)

Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype.
av: Dyer, M, et al.
Publicerad: (1989)

A personal history of the CAMPATH-1H antibody.
av: Waldmann, H
Publicerad: (2002)

Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart.
av: Cheetham, G, et al.
Publicerad: (1998)

T-cell depletion of bone marrow grafts with Campath 1 ex vivo prevents graft-versus-host disease without abrogating the antileukaemic effect of transplantation
av: Novitzky, N, et al.
Publicerad: (1997)

Ex vivo T-cell depletion of bone marrow grafts with campath 1 prevents graft-versus-host disease without abrogating the antileukaemic effect of transplantation.
av: Novitzky, N, et al.
Publicerad: (1997)

In vivo use of Campath-1G to prevent graft-versus-host disease and graft rejection after bone marrow transplantation.
av: Willemze, R, et al.
Publicerad: (1992)