Studies off the opiate control of prolactin, GH and TSH.
Opiate peptides are known to influence the secretion of several anterior pituitary hormones under basal conditions. Further studies on prolactin, GH and TSH have therefore been performed in normal subjects, under basal and stimulated conditions, using an opiate agonist and antagonist. Sixteen mg nal...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1981
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| _version_ | 1826304683844567040 |
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| author | Grossman, A Stubbs, W Gaillard, R Delitala, G Rees, L Besser, G |
| author_facet | Grossman, A Stubbs, W Gaillard, R Delitala, G Rees, L Besser, G |
| author_sort | Grossman, A |
| collection | OXFORD |
| description | Opiate peptides are known to influence the secretion of several anterior pituitary hormones under basal conditions. Further studies on prolactin, GH and TSH have therefore been performed in normal subjects, under basal and stimulated conditions, using an opiate agonist and antagonist. Sixteen mg naloxone had no effect on the basal release of prolactin or GH, but lowered TSH. An infusion of the met-enkephalin analogue DAMME (1 mg) increased GH, and produced an exaggerated response of both prolactin and TSH to 200 micrograms TRH i.v. The peak responses of both prolactin and GH to hypoglycaemia were unaffected by pretreatment with either low-dose (0.4 mg) or high-dose (25 mg) naloxone, or DAMME (0.25 mg). These results suggest that opiate peptides are unlikely to play a major role in the tonic or hypoglycaemia-stimulated release of prolactin and GH, although they may be of importance in the control of TSH. |
| first_indexed | 2024-03-07T06:21:32Z |
| format | Journal article |
| id | oxford-uuid:f2ddfa44-db3f-4845-943b-c77a14ddd09d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:21:32Z |
| publishDate | 1981 |
| record_format | dspace |
| spelling | oxford-uuid:f2ddfa44-db3f-4845-943b-c77a14ddd09d2022-03-27T12:07:28ZStudies off the opiate control of prolactin, GH and TSH.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f2ddfa44-db3f-4845-943b-c77a14ddd09dEnglishSymplectic Elements at Oxford1981Grossman, AStubbs, WGaillard, RDelitala, GRees, LBesser, GOpiate peptides are known to influence the secretion of several anterior pituitary hormones under basal conditions. Further studies on prolactin, GH and TSH have therefore been performed in normal subjects, under basal and stimulated conditions, using an opiate agonist and antagonist. Sixteen mg naloxone had no effect on the basal release of prolactin or GH, but lowered TSH. An infusion of the met-enkephalin analogue DAMME (1 mg) increased GH, and produced an exaggerated response of both prolactin and TSH to 200 micrograms TRH i.v. The peak responses of both prolactin and GH to hypoglycaemia were unaffected by pretreatment with either low-dose (0.4 mg) or high-dose (25 mg) naloxone, or DAMME (0.25 mg). These results suggest that opiate peptides are unlikely to play a major role in the tonic or hypoglycaemia-stimulated release of prolactin and GH, although they may be of importance in the control of TSH. |
| spellingShingle | Grossman, A Stubbs, W Gaillard, R Delitala, G Rees, L Besser, G Studies off the opiate control of prolactin, GH and TSH. |
| title | Studies off the opiate control of prolactin, GH and TSH. |
| title_full | Studies off the opiate control of prolactin, GH and TSH. |
| title_fullStr | Studies off the opiate control of prolactin, GH and TSH. |
| title_full_unstemmed | Studies off the opiate control of prolactin, GH and TSH. |
| title_short | Studies off the opiate control of prolactin, GH and TSH. |
| title_sort | studies off the opiate control of prolactin gh and tsh |
| work_keys_str_mv | AT grossmana studiesofftheopiatecontrolofprolactinghandtsh AT stubbsw studiesofftheopiatecontrolofprolactinghandtsh AT gaillardr studiesofftheopiatecontrolofprolactinghandtsh AT delitalag studiesofftheopiatecontrolofprolactinghandtsh AT reesl studiesofftheopiatecontrolofprolactinghandtsh AT besserg studiesofftheopiatecontrolofprolactinghandtsh |