Control of absolute stereochemistry in transition-metal-catalyzed hydrogen borrowing reactions

Hydrogen borrowing catalysis represents a powerful method for the alkylation of amine or enolate nucleophiles with unactivated alcohols. This approach relies upon a catalyst which can mediate a strategic series of redox events, enabling the formation of C–C and C–N bonds and producing water as the s...

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Huvudupphovsmän: Kwok, T, Hoff, O, Armstrong, RJ, Donohoe, TJ
Materialtyp: Journal article
Språk:English
Publicerad: Wiley 2020
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author Kwok, T
Hoff, O
Armstrong, RJ
Donohoe, TJ
author_facet Kwok, T
Hoff, O
Armstrong, RJ
Donohoe, TJ
author_sort Kwok, T
collection OXFORD
description Hydrogen borrowing catalysis represents a powerful method for the alkylation of amine or enolate nucleophiles with unactivated alcohols. This approach relies upon a catalyst which can mediate a strategic series of redox events, enabling the formation of C–C and C–N bonds and producing water as the sole by‐product. In the majority of cases these reactions have been employed to target achiral or racemic products. In contrast, the focus of this minireview is upon hydrogen borrowing catalyzed reactions in which the absolute stereochemical outcome of the process can be controlled. Asymmetric hydrogen borrowing catalysis is rapidly emerging as a powerful approach for the synthesis of enantioenriched amine and carbonyl containing products and examples involving both C–N and C–C bond formation are presented. A variety of different approaches are discussed including use of chiral auxiliaries, asymmetric catalysis and enantiospecific processes.
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spelling oxford-uuid:f2ec28c7-1f7d-45b1-83c3-d718b09a49772022-03-27T12:07:54ZControl of absolute stereochemistry in transition-metal-catalyzed hydrogen borrowing reactionsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f2ec28c7-1f7d-45b1-83c3-d718b09a4977EnglishSymplectic ElementsWiley2020Kwok, THoff, OArmstrong, RJDonohoe, TJHydrogen borrowing catalysis represents a powerful method for the alkylation of amine or enolate nucleophiles with unactivated alcohols. This approach relies upon a catalyst which can mediate a strategic series of redox events, enabling the formation of C–C and C–N bonds and producing water as the sole by‐product. In the majority of cases these reactions have been employed to target achiral or racemic products. In contrast, the focus of this minireview is upon hydrogen borrowing catalyzed reactions in which the absolute stereochemical outcome of the process can be controlled. Asymmetric hydrogen borrowing catalysis is rapidly emerging as a powerful approach for the synthesis of enantioenriched amine and carbonyl containing products and examples involving both C–N and C–C bond formation are presented. A variety of different approaches are discussed including use of chiral auxiliaries, asymmetric catalysis and enantiospecific processes.
spellingShingle Kwok, T
Hoff, O
Armstrong, RJ
Donohoe, TJ
Control of absolute stereochemistry in transition-metal-catalyzed hydrogen borrowing reactions
title Control of absolute stereochemistry in transition-metal-catalyzed hydrogen borrowing reactions
title_full Control of absolute stereochemistry in transition-metal-catalyzed hydrogen borrowing reactions
title_fullStr Control of absolute stereochemistry in transition-metal-catalyzed hydrogen borrowing reactions
title_full_unstemmed Control of absolute stereochemistry in transition-metal-catalyzed hydrogen borrowing reactions
title_short Control of absolute stereochemistry in transition-metal-catalyzed hydrogen borrowing reactions
title_sort control of absolute stereochemistry in transition metal catalyzed hydrogen borrowing reactions
work_keys_str_mv AT kwokt controlofabsolutestereochemistryintransitionmetalcatalyzedhydrogenborrowingreactions
AT hoffo controlofabsolutestereochemistryintransitionmetalcatalyzedhydrogenborrowingreactions
AT armstrongrj controlofabsolutestereochemistryintransitionmetalcatalyzedhydrogenborrowingreactions
AT donohoetj controlofabsolutestereochemistryintransitionmetalcatalyzedhydrogenborrowingreactions