Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates.

Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates.

Acetamido derivatives of the naturally antibacterial non-β-lactam lactivicin (LTV) have improved activity against their penicillin binding protein targets and reduced hydrolysis by β-lactamases, but penetration into Gram-negative bacteria is still relatively poor. Here we report that modification of...

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Bibliographische Detailangaben
Hauptverfasser: Calvopiña, K, Umland, K, Rydzik, A, Hinchliffe, P, Brem, J, Spencer, J, Schofield, C, Avison, M
Format: Journal article
Sprache:English
Veröffentlicht: American Society for Microbiology 2016

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