Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon
Circumsporozoite protein (CSP) variants of P. vivax, besides having variations in the protein repetitive portion, can differ from each other in aspects such as geographical distribution, intensity of transmission, vectorial competence and immune response. Such aspects must be considered to P. vivax...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Research
2020
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| _version_ | 1826304707725885440 |
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| author | Soares, IF López-Camacho, C Rodrigues-da-Silva, RN da Silva Matos, A de Oliveira Baptista, B Totino, PRR de Souza, RM Harrison, K Gimenez, AM de Freitas, EO Kim, YC Oliveira-Ferreira, J Daniel-Ribeiro, CT Reyes-Sandoval, A Pratt-Riccio, LR Lima-Junior, JDC |
| author_facet | Soares, IF López-Camacho, C Rodrigues-da-Silva, RN da Silva Matos, A de Oliveira Baptista, B Totino, PRR de Souza, RM Harrison, K Gimenez, AM de Freitas, EO Kim, YC Oliveira-Ferreira, J Daniel-Ribeiro, CT Reyes-Sandoval, A Pratt-Riccio, LR Lima-Junior, JDC |
| author_sort | Soares, IF |
| collection | OXFORD |
| description | Circumsporozoite protein (CSP) variants of P. vivax, besides having variations in the protein
repetitive portion, can differ from each other in aspects such as geographical distribution, intensity
of transmission, vectorial competence and immune response. Such aspects must be considered to
P. vivax vaccine development. Therefore, we evaluated the immunogenicity of novel recombinant
proteins corresponding to each of the three P. vivax allelic variants (VK210, VK247 and P. vivax-like)
and of the C-terminal region (shared by all PvCSP variants) in naturally malaria-exposed populations
of Brazilian Amazon. Our results demonstrated that PvCSP-VK210 was the major target of humoral
immune response in studied population, presenting higher frequency and magnitude of IgG response.
The IgG subclass profile showed a prevalence of cytophilic antibodies (IgG1 and IgG3), that seem to
have an essential role in protective immune response. Differently of PvCSP allelic variants, antibodies
elicited against C-terminal region of protein did not correlate with epidemiological parameters,
bringing additional evidence that humoral response against this protein region is not essential to
protective immunity. Taken together, these findings increase the knowledge on serological response
to distinct PvCSP allelic variants and may contribute to the development of a global and effective P.
vivax vaccine.. |
| first_indexed | 2024-03-07T06:21:54Z |
| format | Journal article |
| id | oxford-uuid:f2fbd7c3-f63d-444d-bb01-75471538efb3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:21:54Z |
| publishDate | 2020 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:f2fbd7c3-f63d-444d-bb01-75471538efb32022-03-27T12:08:25ZRecombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian AmazonJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f2fbd7c3-f63d-444d-bb01-75471538efb3EnglishSymplectic ElementsNature Research2020Soares, IFLópez-Camacho, CRodrigues-da-Silva, RNda Silva Matos, Ade Oliveira Baptista, BTotino, PRRde Souza, RMHarrison, KGimenez, AMde Freitas, EOKim, YCOliveira-Ferreira, JDaniel-Ribeiro, CTReyes-Sandoval, APratt-Riccio, LRLima-Junior, JDCCircumsporozoite protein (CSP) variants of P. vivax, besides having variations in the protein repetitive portion, can differ from each other in aspects such as geographical distribution, intensity of transmission, vectorial competence and immune response. Such aspects must be considered to P. vivax vaccine development. Therefore, we evaluated the immunogenicity of novel recombinant proteins corresponding to each of the three P. vivax allelic variants (VK210, VK247 and P. vivax-like) and of the C-terminal region (shared by all PvCSP variants) in naturally malaria-exposed populations of Brazilian Amazon. Our results demonstrated that PvCSP-VK210 was the major target of humoral immune response in studied population, presenting higher frequency and magnitude of IgG response. The IgG subclass profile showed a prevalence of cytophilic antibodies (IgG1 and IgG3), that seem to have an essential role in protective immune response. Differently of PvCSP allelic variants, antibodies elicited against C-terminal region of protein did not correlate with epidemiological parameters, bringing additional evidence that humoral response against this protein region is not essential to protective immunity. Taken together, these findings increase the knowledge on serological response to distinct PvCSP allelic variants and may contribute to the development of a global and effective P. vivax vaccine.. |
| spellingShingle | Soares, IF López-Camacho, C Rodrigues-da-Silva, RN da Silva Matos, A de Oliveira Baptista, B Totino, PRR de Souza, RM Harrison, K Gimenez, AM de Freitas, EO Kim, YC Oliveira-Ferreira, J Daniel-Ribeiro, CT Reyes-Sandoval, A Pratt-Riccio, LR Lima-Junior, JDC Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| title | Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| title_full | Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| title_fullStr | Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| title_full_unstemmed | Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| title_short | Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| title_sort | recombinant plasmodium vivax circumsporozoite surface protein allelic variants antibody recognition by individuals from three communities in the brazilian amazon |
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