A single amino acid residue regulates PTEN-binding and stability of the spinal muscular atrophy protein SMN

A single amino acid residue regulates PTEN-binding and stability of the spinal muscular atrophy protein SMN

Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by decreased levels of the survival of motoneuron (SMN) protein. Post-translational mechanisms for regulation of its stability are still elusive. Thus, we aimed to identify regulatory phosphorylation sites that modulate function and sta...

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Detalhes bibliográficos
Main Authors: Rademacher, S, Detering, NT, Schüning, T, Lindner, R, Santonicola, P, Wefel, I-M, Dehus, J, Walter, LM, Brinkmann, H, Niewienda, A, Janek, K, Varela, MA, Bowerman, M, Di Schiavi, E, Claus, P
Formato: Journal article
Idioma:English
Publicado em: MDPI 2020

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