Melittin enables efficient vesicular escape and enhanced nuclear access of nonviral gene delivery vectors

<p style="text-align:justify;"> Entry of exogenously applied DNA into the cytoplasm and subsequent transport into the nucleus are major cellular barriers for nonviral gene delivery vectors. To overcome these barriers, we have covalently attached the cationic peptide melittin to poly...

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Detalhes bibliográficos
Main Authors: Ogris, M, Carlisle, RC, Bettinger, T, Seymour, LW
Formato: Journal article
Idioma:English
Publicado em: American Society for Biochemistry and Molecular Biology 2001