Igf2 ligand dependency of Pten +- developmental and tumour phenotypes in the mouse

Igf2 ligand dependency of Pten +- developmental and tumour phenotypes in the mouse

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The tumour suppressor PTEN is a key negative regulator of the PI3K-Akt pathway, and is frequently either reduced or lost in human tumours. Murine genetic studies have confirmed that reduction of Pten promotes tumourigenesis in multiple organs, and demonstrated dependency of tumour development on the...

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Bibliographic Details
Main Authors:	Church, D, Phillips, B, Stuckey, D, Barnes, D, Buffa, F, Manek, S, Clarke, K, Harris, A, Carter, E, Hassan, AB
Format:	Journal article
Language:	English
Published:	2012

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