Applications of RNA interference high-throughput screening technology in cancer biology and virology.
RNA interference (RNAi) is an ancient intra-cellular mechanism that regulates gene expression and cell function. Large-scale gene silencing using RNAi high-throughput screening (HTS) has opened an exciting frontier to systematically study gene function in mammalian cells. This approach enables resea...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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| _version_ | 1797103641559040000 |
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| author | Gao, S Yang, C Jiang, S Xu, X Lu, X He, Y Cheung, A Wang, H |
| author_facet | Gao, S Yang, C Jiang, S Xu, X Lu, X He, Y Cheung, A Wang, H |
| author_sort | Gao, S |
| collection | OXFORD |
| description | RNA interference (RNAi) is an ancient intra-cellular mechanism that regulates gene expression and cell function. Large-scale gene silencing using RNAi high-throughput screening (HTS) has opened an exciting frontier to systematically study gene function in mammalian cells. This approach enables researchers to identify gene function in a given biological context and will provide considerable novel insight. Here, we review RNAi HTS strategies and applications using case studies in cancer biology and virology. |
| first_indexed | 2024-03-07T06:22:58Z |
| format | Journal article |
| id | oxford-uuid:f34c27d6-dc59-4e2f-a297-7f0a28970068 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:22:58Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:f34c27d6-dc59-4e2f-a297-7f0a289700682022-03-27T12:11:04ZApplications of RNA interference high-throughput screening technology in cancer biology and virology.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f34c27d6-dc59-4e2f-a297-7f0a28970068EnglishSymplectic Elements at Oxford2014Gao, SYang, CJiang, SXu, XLu, XHe, YCheung, AWang, HRNA interference (RNAi) is an ancient intra-cellular mechanism that regulates gene expression and cell function. Large-scale gene silencing using RNAi high-throughput screening (HTS) has opened an exciting frontier to systematically study gene function in mammalian cells. This approach enables researchers to identify gene function in a given biological context and will provide considerable novel insight. Here, we review RNAi HTS strategies and applications using case studies in cancer biology and virology. |
| spellingShingle | Gao, S Yang, C Jiang, S Xu, X Lu, X He, Y Cheung, A Wang, H Applications of RNA interference high-throughput screening technology in cancer biology and virology. |
| title | Applications of RNA interference high-throughput screening technology in cancer biology and virology. |
| title_full | Applications of RNA interference high-throughput screening technology in cancer biology and virology. |
| title_fullStr | Applications of RNA interference high-throughput screening technology in cancer biology and virology. |
| title_full_unstemmed | Applications of RNA interference high-throughput screening technology in cancer biology and virology. |
| title_short | Applications of RNA interference high-throughput screening technology in cancer biology and virology. |
| title_sort | applications of rna interference high throughput screening technology in cancer biology and virology |
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