Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α (ERα) positive breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake. Here we show that the glutamine transporter, SNAT2, is the AA transporter most freque...

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Bibliographic Details
Main Authors:	Morotti, M, Bridges, E, Valli, A, Choudhry, H, Sheldon, H, Wigfield, S, Gray, N, Zois, C, Grimm, F, Jones, D, Teoh, EJ, Wei-Chen, C, Anastasiou, D, Haider, S, McIntyre, A, Goberdhan, DCI, Buffa, F, Harris, AL, Lord, SR
Format:	Journal article
Published:	National Academy of Sciences 2019

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