Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level.

Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level.

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Failure of the adaptive immune response to control infection with the hepatitis C virus (HCV) can result from mutational escape in targeted T-cell epitopes. Recent studies suggest that T-cell immune pressure is an important factor in the evolution of the nonstructural proteins in HCV. The aim of thi...

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Bibliographic Details
Main Authors: Neumann-Haefelin, C, Frick, D, Wang, J, Pybus, O, Salloum, S, Narula, G, Eckart, A, Biezynski, A, Eiermann, T, Klenerman, P, Viazov, S, Roggendorf, M, Thimme, R, Reiser, M, Timm, J
Format: Journal article
Language:English
Published: 2008

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