Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.

The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many gene regulatory pathways and protein acetylation events. Although p300 inhibitors have been reported, a potent, selective, and readily available active-site-directed small molecule inhibitor is not yet k...

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Bibliographic Details
Main Authors: Bowers, E, Yan, G, Mukherjee, C, Orry, A, Wang, L, Holbert, M, Crump, N, Hazzalin, C, Liszczak, G, Yuan, H, Larocca, C, Saldanha, SA, Abagyan, R, Sun, Y, Meyers, D, Marmorstein, R, Mahadevan, L, Alani, R, Cole, P
Format: Journal article
Language:English
Published: 2010

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