Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever
We have previously demonstrated that Mucosal-Associated Invariant T (MAIT) cells secrete multiple cytokines after exposure to Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever in humans. However, whether cytokine secreting MAIT cells can enhance or attenuate the clin...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2022
|
| _version_ | 1797107542843719680 |
|---|---|
| author | Salerno-Gonçalves, R Fresnay, S Magder, L Darton, TC Waddington, CS Blohmke, CJ Angus, B Levine, MM Pollard, AJ Sztein, MB |
| author_facet | Salerno-Gonçalves, R Fresnay, S Magder, L Darton, TC Waddington, CS Blohmke, CJ Angus, B Levine, MM Pollard, AJ Sztein, MB |
| author_sort | Salerno-Gonçalves, R |
| collection | OXFORD |
| description | We have previously demonstrated that Mucosal-Associated Invariant T (MAIT) cells secrete multiple cytokines after exposure to Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever in humans. However, whether cytokine secreting MAIT cells can enhance or attenuate the clinical severity of bacterial infections remain debatable. This study characterizes human MAIT cell functions in subjects participating in a wild-type S. Typhi human challenge model. Here, we found that MAIT cells exhibit distinct functional signatures associated with protection against typhoid fever. We also observed that the cytokine patterns of MAIT cell responses, rather than the average number of cytokines expressed, are more predictive of typhoid fever outcomes. These results might enable us to objectively, based on functional parameters, identify cytokine patterns that may serve as predictive biomarkers during natural infection and vaccination. |
| first_indexed | 2024-03-07T07:16:06Z |
| format | Journal article |
| id | oxford-uuid:f3ac0063-0e58-42b3-9437-3b18f861646c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:16:06Z |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:f3ac0063-0e58-42b3-9437-3b18f861646c2022-08-10T13:33:00ZMucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid feverJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f3ac0063-0e58-42b3-9437-3b18f861646cEnglishSymplectic ElementsElsevier2022Salerno-Gonçalves, RFresnay, SMagder, LDarton, TCWaddington, CSBlohmke, CJAngus, BLevine, MMPollard, AJSztein, MBWe have previously demonstrated that Mucosal-Associated Invariant T (MAIT) cells secrete multiple cytokines after exposure to Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever in humans. However, whether cytokine secreting MAIT cells can enhance or attenuate the clinical severity of bacterial infections remain debatable. This study characterizes human MAIT cell functions in subjects participating in a wild-type S. Typhi human challenge model. Here, we found that MAIT cells exhibit distinct functional signatures associated with protection against typhoid fever. We also observed that the cytokine patterns of MAIT cell responses, rather than the average number of cytokines expressed, are more predictive of typhoid fever outcomes. These results might enable us to objectively, based on functional parameters, identify cytokine patterns that may serve as predictive biomarkers during natural infection and vaccination. |
| spellingShingle | Salerno-Gonçalves, R Fresnay, S Magder, L Darton, TC Waddington, CS Blohmke, CJ Angus, B Levine, MM Pollard, AJ Sztein, MB Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever |
| title | Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever |
| title_full | Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever |
| title_fullStr | Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever |
| title_full_unstemmed | Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever |
| title_short | Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever |
| title_sort | mucosal associated invariant t cells exhibit distinct functional signatures associated with protection against typhoid fever |
| work_keys_str_mv | AT salernogoncalvesr mucosalassociatedinvarianttcellsexhibitdistinctfunctionalsignaturesassociatedwithprotectionagainsttyphoidfever AT fresnays mucosalassociatedinvarianttcellsexhibitdistinctfunctionalsignaturesassociatedwithprotectionagainsttyphoidfever AT magderl mucosalassociatedinvarianttcellsexhibitdistinctfunctionalsignaturesassociatedwithprotectionagainsttyphoidfever AT dartontc mucosalassociatedinvarianttcellsexhibitdistinctfunctionalsignaturesassociatedwithprotectionagainsttyphoidfever AT waddingtoncs mucosalassociatedinvarianttcellsexhibitdistinctfunctionalsignaturesassociatedwithprotectionagainsttyphoidfever AT blohmkecj mucosalassociatedinvarianttcellsexhibitdistinctfunctionalsignaturesassociatedwithprotectionagainsttyphoidfever AT angusb mucosalassociatedinvarianttcellsexhibitdistinctfunctionalsignaturesassociatedwithprotectionagainsttyphoidfever AT levinemm mucosalassociatedinvarianttcellsexhibitdistinctfunctionalsignaturesassociatedwithprotectionagainsttyphoidfever AT pollardaj mucosalassociatedinvarianttcellsexhibitdistinctfunctionalsignaturesassociatedwithprotectionagainsttyphoidfever AT szteinmb mucosalassociatedinvarianttcellsexhibitdistinctfunctionalsignaturesassociatedwithprotectionagainsttyphoidfever |