Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.
Malformations of the septum, outflow tract and aortic arch are the most common congenital cardiovascular defects and occur in mice lacking Cited2, a transcriptional coactivator of TFAP2. Here we show that Cited2(-/-) mice also develop laterality defects, including right isomerism, abnormal cardiac l...
Main Authors: | Bamforth, S, Bragança, J, Farthing, C, Schneider, J, Broadbent, C, Michell, A, Clarke, K, Neubauer, S, Norris, D, Brown, N, Anderson, R, Bhattacharya, S |
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Format: | Journal article |
Language: | English |
Published: |
2004
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