RNA m 6 A modification, signals for degradation or stabilisation?
The RNA modification N6-methyladenosine (m6A) is conserved across eukaryotes, and profoundly influences RNA metabolism, including regulating RNA stability. METTL3 and METTL14, together with several accessory components, form a ‘writer’ complex catalysing m6A modification. Conversely, FTO and ALKBH5...
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| Format: | Journal article |
| Language: | English |
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Portland Press
2024
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| _version_ | 1826313640048852992 |
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| author | Wei, G |
| author_facet | Wei, G |
| author_sort | Wei, G |
| collection | OXFORD |
| description | The RNA modification N6-methyladenosine (m6A) is conserved across eukaryotes, and profoundly influences RNA metabolism, including regulating RNA stability. METTL3 and METTL14, together with several accessory components, form a ‘writer’ complex catalysing m6A modification. Conversely, FTO and ALKBH5 function as demethylases, rendering m6A dynamic. Key to understanding the functional significance of m6A is its ‘reader' proteins, exemplified by YTH-domain-containing proteins (YTHDFs) canonical reader and insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) non-canonical reader. These proteins play a crucial role in determining RNA stability: YTHDFs mainly promote mRNA degradation through different cytoplasmic pathways, whereas IGF2BPs function to maintain mRNA stability. Additionally, YTHDC1 functions within the nucleus to degrade or protect certain m6A-containing RNAs, and other non-canonical readers also contribute to RNA stability regulation. Notably, m6A regulates retrotransposon LINE1 RNA stability and/or transcription via multiple mechanisms. However, conflicting observations underscore the complexities underlying m6A's regulation of RNA stability depending upon the RNA sequence/structure context, developmental stage, and/or cellular environment. Understanding the interplay between m6A and other RNA regulatory elements is pivotal in deciphering the multifaceted roles m6A plays in RNA stability regulation and broader cellular biology. |
| first_indexed | 2024-09-25T04:16:18Z |
| format | Journal article |
| id | oxford-uuid:f3b9d386-a6f4-4a59-8590-2a6e202ccc28 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:16:18Z |
| publishDate | 2024 |
| publisher | Portland Press |
| record_format | dspace |
| spelling | oxford-uuid:f3b9d386-a6f4-4a59-8590-2a6e202ccc282024-07-20T14:39:46ZRNA m 6 A modification, signals for degradation or stabilisation?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f3b9d386-a6f4-4a59-8590-2a6e202ccc28EnglishJisc Publications RouterPortland Press2024Wei, GThe RNA modification N6-methyladenosine (m6A) is conserved across eukaryotes, and profoundly influences RNA metabolism, including regulating RNA stability. METTL3 and METTL14, together with several accessory components, form a ‘writer’ complex catalysing m6A modification. Conversely, FTO and ALKBH5 function as demethylases, rendering m6A dynamic. Key to understanding the functional significance of m6A is its ‘reader' proteins, exemplified by YTH-domain-containing proteins (YTHDFs) canonical reader and insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) non-canonical reader. These proteins play a crucial role in determining RNA stability: YTHDFs mainly promote mRNA degradation through different cytoplasmic pathways, whereas IGF2BPs function to maintain mRNA stability. Additionally, YTHDC1 functions within the nucleus to degrade or protect certain m6A-containing RNAs, and other non-canonical readers also contribute to RNA stability regulation. Notably, m6A regulates retrotransposon LINE1 RNA stability and/or transcription via multiple mechanisms. However, conflicting observations underscore the complexities underlying m6A's regulation of RNA stability depending upon the RNA sequence/structure context, developmental stage, and/or cellular environment. Understanding the interplay between m6A and other RNA regulatory elements is pivotal in deciphering the multifaceted roles m6A plays in RNA stability regulation and broader cellular biology. |
| spellingShingle | Wei, G RNA m 6 A modification, signals for degradation or stabilisation? |
| title | RNA m 6 A modification, signals for degradation or stabilisation? |
| title_full | RNA m 6 A modification, signals for degradation or stabilisation? |
| title_fullStr | RNA m 6 A modification, signals for degradation or stabilisation? |
| title_full_unstemmed | RNA m 6 A modification, signals for degradation or stabilisation? |
| title_short | RNA m 6 A modification, signals for degradation or stabilisation? |
| title_sort | rna m 6 a modification signals for degradation or stabilisation |
| work_keys_str_mv | AT weig rnam6amodificationsignalsfordegradationorstabilisation |