Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva
Background: Mutations in the ALK2 kinase cause extraskeletal bone formation. Results: We solved the structure of ALK2 in complex with the inhibitor FKBP12. Conclusion: Disease mutations break critical interactions that stabilize the inactive ALK2-FKBP12 complex leading to kinase activation. Signific...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Published: |
2012
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