Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes
Photo-regulated transmembrane ionophores enable spatial and temporal control over activity, offering promise as targeted therapeutics. Key to such applications is control using bio-compatible visible light. Herein, we report red-shifted azobenzene-derived synthetic anionophores that use amber or red...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Wiley
2024
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| _version_ | 1817930726079725568 |
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| author | Kerckhoffs, A Ahmad, M Langton, ML |
| author_facet | Kerckhoffs, A Ahmad, M Langton, ML |
| author_sort | Kerckhoffs, A |
| collection | OXFORD |
| description | Photo-regulated transmembrane ionophores enable spatial and temporal control over activity, offering promise as targeted therapeutics. Key to such applications is control using bio-compatible visible light. Herein, we report red-shifted azobenzene-derived synthetic anionophores that use amber or red light to trigger (E)-(Z) photoisomerisation and activation of transmembrane chloride transport. We demonstrate that by tuning the thermal half-life of the more active, but thermodynamically unstable, Z isomer to relax on the timescale of minutes, transient activation of ion transport can be achieved by activating with solely with visible light and deactivating by thermal relaxation. |
| first_indexed | 2024-09-25T04:19:41Z |
| format | Journal article |
| id | oxford-uuid:f3f3a081-49f0-42a7-bda2-3e2a170a3d7c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:10:42Z |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:f3f3a081-49f0-42a7-bda2-3e2a170a3d7c2024-10-01T10:01:34ZTransient photoactivation of anionophores by using redshifted fast-relaxing azobenzenesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f3f3a081-49f0-42a7-bda2-3e2a170a3d7cEnglishSymplectic ElementsWiley2024Kerckhoffs, AAhmad, MLangton, MLPhoto-regulated transmembrane ionophores enable spatial and temporal control over activity, offering promise as targeted therapeutics. Key to such applications is control using bio-compatible visible light. Herein, we report red-shifted azobenzene-derived synthetic anionophores that use amber or red light to trigger (E)-(Z) photoisomerisation and activation of transmembrane chloride transport. We demonstrate that by tuning the thermal half-life of the more active, but thermodynamically unstable, Z isomer to relax on the timescale of minutes, transient activation of ion transport can be achieved by activating with solely with visible light and deactivating by thermal relaxation. |
| spellingShingle | Kerckhoffs, A Ahmad, M Langton, ML Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes |
| title | Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes |
| title_full | Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes |
| title_fullStr | Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes |
| title_full_unstemmed | Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes |
| title_short | Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes |
| title_sort | transient photoactivation of anionophores by using redshifted fast relaxing azobenzenes |
| work_keys_str_mv | AT kerckhoffsa transientphotoactivationofanionophoresbyusingredshiftedfastrelaxingazobenzenes AT ahmadm transientphotoactivationofanionophoresbyusingredshiftedfastrelaxingazobenzenes AT langtonml transientphotoactivationofanionophoresbyusingredshiftedfastrelaxingazobenzenes |