Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes
<p>Photo-regulated transmembrane ionophores enable spatial and temporal control over activity, offering promise as targeted therapeutics. Key to such applications is control using bio-compatible visible light. Herein, we report red-shifted azobenzene-derived synthetic anionophores that use amb...
Main Authors: | , , |
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Format: | Journal article |
Language: | English |
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Wiley
2024
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_version_ | 1811140293718704128 |
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author | Kerckhoffs, A Ahmad, M Langton, ML |
author_facet | Kerckhoffs, A Ahmad, M Langton, ML |
author_sort | Kerckhoffs, A |
collection | OXFORD |
description | <p>Photo-regulated transmembrane ionophores enable spatial and temporal control over activity, offering promise as targeted therapeutics. Key to such applications is control using bio-compatible visible light. Herein, we report red-shifted azobenzene-derived synthetic anionophores that use amber or red light to trigger (E)-(Z) photoisomerisation and activation of transmembrane chloride transport. We demonstrate that by tuning the thermal half-life of the more active, but thermodynamically unstable, Z isomer to relax on the timescale of minutes, transient activation of ion transport can be achieved by activating solely with visible light and deactivating by thermal relaxation.</p> |
first_indexed | 2024-09-25T04:19:41Z |
format | Journal article |
id | oxford-uuid:f3f3a081-49f0-42a7-bda2-3e2a170a3d7c |
institution | University of Oxford |
language | English |
last_indexed | 2024-09-25T04:19:41Z |
publishDate | 2024 |
publisher | Wiley |
record_format | dspace |
spelling | oxford-uuid:f3f3a081-49f0-42a7-bda2-3e2a170a3d7c2024-08-01T13:12:05ZTransient photoactivation of anionophores by using redshifted fast-relaxing azobenzenesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f3f3a081-49f0-42a7-bda2-3e2a170a3d7cEnglishSymplectic ElementsWiley2024Kerckhoffs, AAhmad, MLangton, ML<p>Photo-regulated transmembrane ionophores enable spatial and temporal control over activity, offering promise as targeted therapeutics. Key to such applications is control using bio-compatible visible light. Herein, we report red-shifted azobenzene-derived synthetic anionophores that use amber or red light to trigger (E)-(Z) photoisomerisation and activation of transmembrane chloride transport. We demonstrate that by tuning the thermal half-life of the more active, but thermodynamically unstable, Z isomer to relax on the timescale of minutes, transient activation of ion transport can be achieved by activating solely with visible light and deactivating by thermal relaxation.</p> |
spellingShingle | Kerckhoffs, A Ahmad, M Langton, ML Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes |
title | Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes |
title_full | Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes |
title_fullStr | Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes |
title_full_unstemmed | Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes |
title_short | Transient photoactivation of anionophores by using redshifted fast-relaxing azobenzenes |
title_sort | transient photoactivation of anionophores by using redshifted fast relaxing azobenzenes |
work_keys_str_mv | AT kerckhoffsa transientphotoactivationofanionophoresbyusingredshiftedfastrelaxingazobenzenes AT ahmadm transientphotoactivationofanionophoresbyusingredshiftedfastrelaxingazobenzenes AT langtonml transientphotoactivationofanionophoresbyusingredshiftedfastrelaxingazobenzenes |