Effects of niacin on atherosclerosis and vascular function.
PURPOSE OF REVIEW: Niacin has been used for more than 50 years in the management of atherosclerosis and is associated with improved patient outcomes. The routine use of niacin has been superseded in recent years with the advent of newer lipid-modulating interventions. Recently, however, there has b...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1826304918231711744 |
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| author | Ruparelia, N Digby, J Choudhury, R |
| author_facet | Ruparelia, N Digby, J Choudhury, R |
| author_sort | Ruparelia, N |
| collection | OXFORD |
| description | PURPOSE OF REVIEW: Niacin has been used for more than 50 years in the management of atherosclerosis and is associated with improved patient outcomes. The routine use of niacin has been superseded in recent years with the advent of newer lipid-modulating interventions. Recently, however, there has been a renewed interest in its use due to the appreciation of its many beneficial effects on atherosclerosis and endothelial function, both 'lipid-targeted' and 'pleiotropic'. This review will consider the effects of niacin in the setting of clinical trials and will critically evaluate proposed mechanisms of action. RECENT FINDINGS: The identification of the GPR109A receptor has promoted a greater insight into niacin's mechanism of action, with demonstrated beneficial effects on endothelial function and inflammation, in addition to its lipid modulation role. SUMMARY: Whether niacin itself is used routinely in the future will depend on the outcomes of two large outcome trials (AIM-HIGH and HPS2-THRIVE). In the future, however, with even better understanding of niacin pharmacology, new drugs may be able to be engineered to capture aspects of niacin that capitalize on the benefits more specifically and also more selectively, to avoid troublesome side-effects. |
| first_indexed | 2024-03-07T06:24:59Z |
| format | Journal article |
| id | oxford-uuid:f3f98342-d94b-4b6a-b07f-6c5904a8305c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:24:59Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:f3f98342-d94b-4b6a-b07f-6c5904a8305c2022-03-27T12:16:14ZEffects of niacin on atherosclerosis and vascular function.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f3f98342-d94b-4b6a-b07f-6c5904a8305cEnglishSymplectic Elements at Oxford2011Ruparelia, NDigby, JChoudhury, R PURPOSE OF REVIEW: Niacin has been used for more than 50 years in the management of atherosclerosis and is associated with improved patient outcomes. The routine use of niacin has been superseded in recent years with the advent of newer lipid-modulating interventions. Recently, however, there has been a renewed interest in its use due to the appreciation of its many beneficial effects on atherosclerosis and endothelial function, both 'lipid-targeted' and 'pleiotropic'. This review will consider the effects of niacin in the setting of clinical trials and will critically evaluate proposed mechanisms of action. RECENT FINDINGS: The identification of the GPR109A receptor has promoted a greater insight into niacin's mechanism of action, with demonstrated beneficial effects on endothelial function and inflammation, in addition to its lipid modulation role. SUMMARY: Whether niacin itself is used routinely in the future will depend on the outcomes of two large outcome trials (AIM-HIGH and HPS2-THRIVE). In the future, however, with even better understanding of niacin pharmacology, new drugs may be able to be engineered to capture aspects of niacin that capitalize on the benefits more specifically and also more selectively, to avoid troublesome side-effects. |
| spellingShingle | Ruparelia, N Digby, J Choudhury, R Effects of niacin on atherosclerosis and vascular function. |
| title | Effects of niacin on atherosclerosis and vascular function. |
| title_full | Effects of niacin on atherosclerosis and vascular function. |
| title_fullStr | Effects of niacin on atherosclerosis and vascular function. |
| title_full_unstemmed | Effects of niacin on atherosclerosis and vascular function. |
| title_short | Effects of niacin on atherosclerosis and vascular function. |
| title_sort | effects of niacin on atherosclerosis and vascular function |
| work_keys_str_mv | AT ruparelian effectsofniacinonatherosclerosisandvascularfunction AT digbyj effectsofniacinonatherosclerosisandvascularfunction AT choudhuryr effectsofniacinonatherosclerosisandvascularfunction |