Initiation of T cell signaling by CD45 segregation at 'close contacts'

Initiation of T cell signaling by CD45 segregation at 'close contacts'

It has been proposed that the local segregation of kinases and the tyrosine phosphatase CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs and whether it can initiate signaling is unclear. Using structural and biophysical analysis, we show that the extracellular...

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Hlavní autoři: Chang, VT, Fernandes, RA, Ganzinger, KA, Lee, SF, Siebold, C, McColl, J, Jönsson, P, Palayret, M, Harlos, K, Coles, CH, Jones, EY, Lui, Y, Huang, E, Gilbert, RJC, Klenerman, D, Aricescu, AR, Davis, SJ
Médium: Journal article
Jazyk:English
Vydáno: Nature Publishing Group 2016

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