Initiation of T cell signaling by CD45 segregation at 'close contacts'

It has been proposed that the local segregation of kinases and the tyrosine phosphatase CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs and whether it can initiate signaling is unclear. Using structural and biophysical analysis, we show that the extracellular...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Chang, VT, Fernandes, RA, Ganzinger, KA, Lee, SF, Siebold, C, McColl, J, Jönsson, P, Palayret, M, Harlos, K, Coles, CH, Jones, EY, Lui, Y, Huang, E, Gilbert, RJC, Klenerman, D, Aricescu, AR, Davis, SJ
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Nature Publishing Group 2016