Non-apoptotic Caspase regulation of stem cell properties
The evolutionarily conserved family of proteins called caspase are the main factors mediating the orchestrated programme of cell suicide known as apoptosis. Since this protein family was associated with this essential biological function, the majority of scientific efforts were focused towards under...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2017
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| _version_ | 1797103805670621184 |
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| author | Baena-Lopez, LA Arthurton, L Xu, DC Galasso, A |
| author_facet | Baena-Lopez, LA Arthurton, L Xu, DC Galasso, A |
| author_sort | Baena-Lopez, LA |
| collection | OXFORD |
| description | The evolutionarily conserved family of proteins called caspase are the main factors mediating the orchestrated programme of cell suicide known as apoptosis. Since this protein family was associated with this essential biological function, the majority of scientific efforts were focused towards understanding their molecular activation and function during cell death. However, an emerging body of evidence has highlighted a repertoire of non-lethal roles within a large variety of cell types, including stem cells. Here we intend to provide a comprehensive overview of the key role of caspases as regulators of stem cell properties. Finally, we briefly discuss the possible pathological consequences of caspase malfunction in stem cells, and the therapeutic potential of caspase regulation applied to this context. |
| first_indexed | 2024-03-07T06:25:11Z |
| format | Journal article |
| id | oxford-uuid:f409a08e-070f-4e32-a11a-e8e43b4da88f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:25:11Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:f409a08e-070f-4e32-a11a-e8e43b4da88f2022-03-27T12:16:48ZNon-apoptotic Caspase regulation of stem cell propertiesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f409a08e-070f-4e32-a11a-e8e43b4da88fEnglishSymplectic Elements at OxfordElsevier2017Baena-Lopez, LAArthurton, LXu, DCGalasso, AThe evolutionarily conserved family of proteins called caspase are the main factors mediating the orchestrated programme of cell suicide known as apoptosis. Since this protein family was associated with this essential biological function, the majority of scientific efforts were focused towards understanding their molecular activation and function during cell death. However, an emerging body of evidence has highlighted a repertoire of non-lethal roles within a large variety of cell types, including stem cells. Here we intend to provide a comprehensive overview of the key role of caspases as regulators of stem cell properties. Finally, we briefly discuss the possible pathological consequences of caspase malfunction in stem cells, and the therapeutic potential of caspase regulation applied to this context. |
| spellingShingle | Baena-Lopez, LA Arthurton, L Xu, DC Galasso, A Non-apoptotic Caspase regulation of stem cell properties |
| title | Non-apoptotic Caspase regulation of stem cell properties |
| title_full | Non-apoptotic Caspase regulation of stem cell properties |
| title_fullStr | Non-apoptotic Caspase regulation of stem cell properties |
| title_full_unstemmed | Non-apoptotic Caspase regulation of stem cell properties |
| title_short | Non-apoptotic Caspase regulation of stem cell properties |
| title_sort | non apoptotic caspase regulation of stem cell properties |
| work_keys_str_mv | AT baenalopezla nonapoptoticcaspaseregulationofstemcellproperties AT arthurtonl nonapoptoticcaspaseregulationofstemcellproperties AT xudc nonapoptoticcaspaseregulationofstemcellproperties AT galassoa nonapoptoticcaspaseregulationofstemcellproperties |