Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma
Pseudotumours are well recognised as a complication of metal-on-metal hip arthroplasties and are thought to develop on the basis of an innate and adaptive immune response to cobalt-chrome (Co-Cr) wear particles. We report a case of a large pseudotumour that developed following a knee endoprosthetic...
| Автори: | , , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
Springer Berlin Heidelberg
2017
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| _version_ | 1826304974467891200 |
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| author | Craig, R Vlychou, M McCarthy, C Gibbons, C Athanasou, N |
| author_facet | Craig, R Vlychou, M McCarthy, C Gibbons, C Athanasou, N |
| author_sort | Craig, R |
| collection | OXFORD |
| description | Pseudotumours are well recognised as a complication of metal-on-metal hip arthroplasties and are thought to develop on the basis of an innate and adaptive immune response to cobalt-chrome (Co-Cr) wear particles. We report a case of a large pseudotumour that developed following a knee endoprosthetic replacement (EPR) undertaken for Ewing sarcoma. The lesion contained necrotic and degenerate connective tissue in which there were numerous scattered metal wear-containing macrophages, eosinophil polymorphs, lymphocytes, plasma cells and aseptic lymphocyte-dominated vascular-associated lesion-like lymphoid aggregates. Metal ion levels were elevated. No evidence of infection or tumour was noted and it was concluded that the lesion was most likely an inflammatory pseudotumour developing on the basis of an innate and adaptive immune response to components of Co-Cr metal wear derived from the knee EPR. |
| first_indexed | 2024-03-07T06:25:51Z |
| format | Journal article |
| id | oxford-uuid:f444744f-df6f-43e3-9439-0140f7d63667 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:25:51Z |
| publishDate | 2017 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | oxford-uuid:f444744f-df6f-43e3-9439-0140f7d636672022-03-27T12:18:27ZMetal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcomaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f444744f-df6f-43e3-9439-0140f7d63667EnglishSymplectic Elements at OxfordSpringer Berlin Heidelberg2017Craig, RVlychou, MMcCarthy, CGibbons, CAthanasou, NPseudotumours are well recognised as a complication of metal-on-metal hip arthroplasties and are thought to develop on the basis of an innate and adaptive immune response to cobalt-chrome (Co-Cr) wear particles. We report a case of a large pseudotumour that developed following a knee endoprosthetic replacement (EPR) undertaken for Ewing sarcoma. The lesion contained necrotic and degenerate connective tissue in which there were numerous scattered metal wear-containing macrophages, eosinophil polymorphs, lymphocytes, plasma cells and aseptic lymphocyte-dominated vascular-associated lesion-like lymphoid aggregates. Metal ion levels were elevated. No evidence of infection or tumour was noted and it was concluded that the lesion was most likely an inflammatory pseudotumour developing on the basis of an innate and adaptive immune response to components of Co-Cr metal wear derived from the knee EPR. |
| spellingShingle | Craig, R Vlychou, M McCarthy, C Gibbons, C Athanasou, N Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma |
| title | Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma |
| title_full | Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma |
| title_fullStr | Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma |
| title_full_unstemmed | Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma |
| title_short | Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma |
| title_sort | metal wear induced pseudotumour following an endoprosthetic knee replacement for ewing sarcoma |
| work_keys_str_mv | AT craigr metalwearinducedpseudotumourfollowinganendoprosthetickneereplacementforewingsarcoma AT vlychoum metalwearinducedpseudotumourfollowinganendoprosthetickneereplacementforewingsarcoma AT mccarthyc metalwearinducedpseudotumourfollowinganendoprosthetickneereplacementforewingsarcoma AT gibbonsc metalwearinducedpseudotumourfollowinganendoprosthetickneereplacementforewingsarcoma AT athanasoun metalwearinducedpseudotumourfollowinganendoprosthetickneereplacementforewingsarcoma |