Salmonella typhimurium displays normal invasion of mice with defective epidermal growth factor receptors.
The role of the epidermal growth factor (EGF) receptor in cell invasion by Salmonella typhimurium was examined in vitro and in vivo by using waved-2 mice which express an EGF receptor with reduced kinase activity. S. typhimurium invaded fibroblasts from waved-2 mice as efficiently as fibroblasts fro...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1995
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| _version_ | 1826304978988302336 |
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| author | McNeil, A Dunstan, S Clark, S Strugnell, R |
| author_facet | McNeil, A Dunstan, S Clark, S Strugnell, R |
| author_sort | McNeil, A |
| collection | OXFORD |
| description | The role of the epidermal growth factor (EGF) receptor in cell invasion by Salmonella typhimurium was examined in vitro and in vivo by using waved-2 mice which express an EGF receptor with reduced kinase activity. S. typhimurium invaded fibroblasts from waved-2 mice as efficiently as fibroblasts from wild-type control animals. In vivo, S. typhimurium both invaded the gastrointestinal tract and penetrated through to the spleen of waved-2 mice. Our studies suggest that the EGF receptor has only a limited role, if any, in cell invasion by S. typhimurium. |
| first_indexed | 2024-03-07T06:25:55Z |
| format | Journal article |
| id | oxford-uuid:f448cad8-fbba-4fd1-ab4c-72a453eb2da7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:25:55Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:f448cad8-fbba-4fd1-ab4c-72a453eb2da72022-03-27T12:18:41ZSalmonella typhimurium displays normal invasion of mice with defective epidermal growth factor receptors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f448cad8-fbba-4fd1-ab4c-72a453eb2da7EnglishSymplectic Elements at Oxford1995McNeil, ADunstan, SClark, SStrugnell, RThe role of the epidermal growth factor (EGF) receptor in cell invasion by Salmonella typhimurium was examined in vitro and in vivo by using waved-2 mice which express an EGF receptor with reduced kinase activity. S. typhimurium invaded fibroblasts from waved-2 mice as efficiently as fibroblasts from wild-type control animals. In vivo, S. typhimurium both invaded the gastrointestinal tract and penetrated through to the spleen of waved-2 mice. Our studies suggest that the EGF receptor has only a limited role, if any, in cell invasion by S. typhimurium. |
| spellingShingle | McNeil, A Dunstan, S Clark, S Strugnell, R Salmonella typhimurium displays normal invasion of mice with defective epidermal growth factor receptors. |
| title | Salmonella typhimurium displays normal invasion of mice with defective epidermal growth factor receptors. |
| title_full | Salmonella typhimurium displays normal invasion of mice with defective epidermal growth factor receptors. |
| title_fullStr | Salmonella typhimurium displays normal invasion of mice with defective epidermal growth factor receptors. |
| title_full_unstemmed | Salmonella typhimurium displays normal invasion of mice with defective epidermal growth factor receptors. |
| title_short | Salmonella typhimurium displays normal invasion of mice with defective epidermal growth factor receptors. |
| title_sort | salmonella typhimurium displays normal invasion of mice with defective epidermal growth factor receptors |
| work_keys_str_mv | AT mcneila salmonellatyphimuriumdisplaysnormalinvasionofmicewithdefectiveepidermalgrowthfactorreceptors AT dunstans salmonellatyphimuriumdisplaysnormalinvasionofmicewithdefectiveepidermalgrowthfactorreceptors AT clarks salmonellatyphimuriumdisplaysnormalinvasionofmicewithdefectiveepidermalgrowthfactorreceptors AT strugnellr salmonellatyphimuriumdisplaysnormalinvasionofmicewithdefectiveepidermalgrowthfactorreceptors |