Properties of murine (CD8+)CD27- T cells.
In humans, loss of CD27 expression is associated with the stable acquisition of effector functions by CD8+ T cells. We found that murine (CD8+)CD27- T cells were confined to the primed CD62L(dull/-)CD44(bright)CCR7- T cell population. (CD8+)CD27- T cells were absent from lymph nodes but could be fou...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2005
|
| _version_ | 1826305005147127808 |
|---|---|
| author | Baars, P Sierro, S Arens, R Tesselaar, K Hooibrink, B Klenerman, P van Lier, R |
| author_facet | Baars, P Sierro, S Arens, R Tesselaar, K Hooibrink, B Klenerman, P van Lier, R |
| author_sort | Baars, P |
| collection | OXFORD |
| description | In humans, loss of CD27 expression is associated with the stable acquisition of effector functions by CD8+ T cells. We found that murine (CD8+)CD27- T cells were confined to the primed CD62L(dull/-)CD44(bright)CCR7- T cell population. (CD8+)CD27- T cells were absent from lymph nodes but could be found in blood, spleen and in non-lymphoid organs such as lung and liver. Late after primary influenza virus infection, low percentages of antigen-specific CD27- cells emerged in the lung and spleen. After recovery from secondary influenza virus infection, high percentages of influenza-specific CD27- T cells were found in the lung and the loss of CD27 on lung CD8+ T cells coincided with high granzyme B expression. After murine cytomegalovirus infection, loss of CD27 expression on virus-specific CD8+ T cell populations was sustained and especially marked in liver and lung. We suggest that in mice, CD27 is lost from CD8+ T cells only after repetitive antigenic stimulation. Moreover, the high expression of both granzyme B and perforin in the CD27- T cells suggests that the lack of CD27 on murine CD8+ T cells can be used to identify memory T cells with expression of cytotoxic effector molecules. |
| first_indexed | 2024-03-07T06:26:19Z |
| format | Journal article |
| id | oxford-uuid:f46941ca-842a-4908-9a15-9eadf3cfb14a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:26:19Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:f46941ca-842a-4908-9a15-9eadf3cfb14a2022-03-27T12:19:36ZProperties of murine (CD8+)CD27- T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f46941ca-842a-4908-9a15-9eadf3cfb14aEnglishSymplectic Elements at Oxford2005Baars, PSierro, SArens, RTesselaar, KHooibrink, BKlenerman, Pvan Lier, RIn humans, loss of CD27 expression is associated with the stable acquisition of effector functions by CD8+ T cells. We found that murine (CD8+)CD27- T cells were confined to the primed CD62L(dull/-)CD44(bright)CCR7- T cell population. (CD8+)CD27- T cells were absent from lymph nodes but could be found in blood, spleen and in non-lymphoid organs such as lung and liver. Late after primary influenza virus infection, low percentages of antigen-specific CD27- cells emerged in the lung and spleen. After recovery from secondary influenza virus infection, high percentages of influenza-specific CD27- T cells were found in the lung and the loss of CD27 on lung CD8+ T cells coincided with high granzyme B expression. After murine cytomegalovirus infection, loss of CD27 expression on virus-specific CD8+ T cell populations was sustained and especially marked in liver and lung. We suggest that in mice, CD27 is lost from CD8+ T cells only after repetitive antigenic stimulation. Moreover, the high expression of both granzyme B and perforin in the CD27- T cells suggests that the lack of CD27 on murine CD8+ T cells can be used to identify memory T cells with expression of cytotoxic effector molecules. |
| spellingShingle | Baars, P Sierro, S Arens, R Tesselaar, K Hooibrink, B Klenerman, P van Lier, R Properties of murine (CD8+)CD27- T cells. |
| title | Properties of murine (CD8+)CD27- T cells. |
| title_full | Properties of murine (CD8+)CD27- T cells. |
| title_fullStr | Properties of murine (CD8+)CD27- T cells. |
| title_full_unstemmed | Properties of murine (CD8+)CD27- T cells. |
| title_short | Properties of murine (CD8+)CD27- T cells. |
| title_sort | properties of murine cd8 cd27 t cells |
| work_keys_str_mv | AT baarsp propertiesofmurinecd8cd27tcells AT sierros propertiesofmurinecd8cd27tcells AT arensr propertiesofmurinecd8cd27tcells AT tesselaark propertiesofmurinecd8cd27tcells AT hooibrinkb propertiesofmurinecd8cd27tcells AT klenermanp propertiesofmurinecd8cd27tcells AT vanlierr propertiesofmurinecd8cd27tcells |