Manganese accumulation in pancreatic beta-cells and its stimulation by glucose.

Manganese accumulation in pancreatic beta-cells and its stimulation by glucose.

Electrothermal atomic-absorption spectroscopy was employed for measuring manganese in beta-cell-rich pancreatic islets microdissected from ob/ob mice. The islet content of endogenous manganese was 80 mumol/kg dry wt., which is about half as much as found in the exocrine pancreas. The initial uptake...

Bibliografske podrobnosti
Main Authors:	Rorsman, P, Berggren, P, Hellman, B
Format:	Journal article
Jezik:	English
Izdano:	1982

Podobne knjige/članki

MANGANESE ACCUMULATION IN PANCREATIC B-CELLS DUE TO GLUCOSE INHIBITION OF OUTWARD TRANSPORT
od: Rorsman, P, et al.
Izdano: (1981)

GLUCOSE-INDUCED RETENTION OF MANGANESE IN PANCREATIC BETA-CELLS
od: Rorsman, P
Izdano: (1982)

The interaction between manganese and calcium fluxes in pancreatic beta-cells.
od: Rorsman, P, et al.
Izdano: (1983)

Ca2+ transport in pancreatic beta-cells during glucose stimulation of insulin secretion.
od: Hellman, B, et al.
Izdano: (1980)

Glucose promotes intracellular sequestration of manganese in pancreatic beta-cells.
od: Rorsman, P
Izdano: (1982)

EVIDENCE FOR A PRONOUNCED MITOCHONDRIAL ACCUMULATION OF MANGANESE IN GLUCOSE-STIMULATED PANCREATIC B-CELLS OF OB/OB MICE
od: Rorsman, P
Izdano: (1982)

Calcium and pancreatic beta-cell function. XI. Modification of 45Ca fluxes by Na+ removal.
od: Hellman, B, et al.
Izdano: (1980)

Inositol trisphosphate-dependent periodic activation of a Ca(2+)-activated K+ conductance in glucose-stimulated pancreatic beta-cells.
od: Ammälä, C, et al.
Izdano: (1991)

Dual effects of glucose on the cytosolic Ca2+ activity of mouse pancreatic beta-cells.
od: Rorsman, P, et al.
Izdano: (1984)

Direct evidence for opposite effects of D-glucose and D-glyceraldehyde on cytoplasmic pH of mouse pancreatic beta-cells.
od: Arkhammar, P, et al.
Izdano: (1986)

Glucose-sensing mechanisms in pancreatic beta-cells.
od: MacDonald, P, et al.
Izdano: (2005)

Direct measurements of increased free cytoplasmic Ca2+ in mouse pancreatic beta-cells following stimulation by hypoglycemic sulfonylureas.
od: Abrahamsson, H, et al.
Izdano: (1985)

DIRECT EVIDENCE THAT GLUCOSE BOTH REDUCES AND INCREASES CYTOSOLIC FREE CA-2+ IN MOUSE PANCREATIC BETA-CELLS
od: Rorsman, P, et al.
Izdano: (1984)

DIRECT DETERMINATION OF MANGANESE IN MICROGRAM AMOUNTS OF PANCREATIC TISSUE BY ELECTROTHERMAL ATOMIC-ABSORPTION SPECTROMETRY
od: Rorsman, P, et al.
Izdano: (1982)

Glucose-induced increase in cytoplasmic pH in pancreatic beta-cells is mediated by Na+/H+ exchange, an effect not dependent on protein kinase C.
od: Juntti-Berggren, L, et al.
Izdano: (1991)

Alpha 2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic beta-cells.
od: Bokvist, K, et al.
Izdano: (1991)

Glucose stimulates the entry of Ca2+ into the insulin-producing beta cells but not into the glucagon-producing alpha 2 cells.
od: Wesslén, N, et al.
Izdano: (1987)

Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP.
od: Rorsman, P, et al.
Izdano: (1985)

CYTOPLASMIC PH OF MOUSE PANCREATIC BETA-CELLS AS MEASURED BY THE FLUORESCENT PH-INDICATOR QUENE-1
od: Arkhammar, P, et al.
Izdano: (1986)

PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
od: Eliasson, L, et al.
Izdano: (1996)

Reduction of the cytosolic calcium activity in clonal insulin-releasing cells exposed to glucose.
od: Rorsman, P, et al.
Izdano: (1983)

The dual action of glucose on the cytosolic Ca2+ activity in pancreatic beta-cells. Demonstration of an inhibitory effect of glucose on insulin release in the mouse and man.
od: Hellman, B, et al.
Izdano: (1985)

Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.
od: Bokvist, K, et al.
Izdano: (1991)

Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels.
od: Rorsman, P, et al.
Izdano: (1989)

Electrophysiology of the pancreatic beta-cell.
od: Ashcroft, F, et al.
Izdano: (1989)

Inhibition of L-type calcium channels by internal GTP [gamma S] in mouse pancreatic beta cells.
od: Ammälä, C, et al.
Izdano: (1992)

Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells.
od: Smith, P, et al.
Izdano: (1989)

EVIDENCE THAT GLUCOSE-INDUCED DEPOLARIZATION IN THE PANCREATIC BETA-CELLS INVOLVES THE CLOSURE OF AN ATP-DEPENDENT K+-CHANNEL
od: Rorsman, P, et al.
Izdano: (1985)

CA2+ MOVEMENTS DURING STIMULATION OF INSULIN RELEASE BY REMOVAL OF EXTRACELLULAR NA+
od: Rorsman, P, et al.
Izdano: (1980)

ELECTRICAL BURSTING IN ISLET BETA-CELLS - REPLY
od: Rorsman, P, et al.
Izdano: (1992)

Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation.
od: Kanno, T, et al.
Izdano: (2002)

Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.
od: Arkhammar, P, et al.
Izdano: (1987)

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.
od: Zehetner, J, et al.
Izdano: (2008)

Delayed rectifying and calcium-activated K+ channels and their significance for action potential repolarization in mouse pancreatic beta-cells.
od: Smith, P, et al.
Izdano: (1990)

Insulin granule dynamics in pancreatic beta cells.
od: Rorsman, P, et al.
Izdano: (2003)

D-GLUCOSE AND D-GLYCERALDEHYDE HAVE OPPOSITE EFFECTS ON CYTOPLASMIC PH OF MOUSE PANCREATIC B-CELLS WHEN MEASURED BY THE FLUORESCENT PH-INDICATOR QUENE-1
od: Arkhammar, P, et al.
Izdano: (1986)

CLONIDINE INHIBITION OF GLUCOSE-STIMULATED INSULIN-RELEASE INVOLVES REDUCTION OF THE CA-2+ CURRENT
od: Rorsman, P, et al.
Izdano: (1987)

Stimulation of the KATP channel by ADP and diazoxide requires nucleotide hydrolysis in mouse pancreatic beta-cells.
od: Larsson, O, et al.
Izdano: (1993)

Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells.
od: Smith, P, et al.
Izdano: (1990)

Insulin secretion: Function and therapy of pancreatic beta-cells in diabetes
od: Rorsman, P
Izdano: (2005)