Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor
Chemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone pep...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2017
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| _version_ | 1826305036745965568 |
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| author | Hanauer, T Hopkinson, R Patel, K Li, Y Correddu, D Kawamura, A Sarojini, V Leung, I Gruber, T |
| author_facet | Hanauer, T Hopkinson, R Patel, K Li, Y Correddu, D Kawamura, A Sarojini, V Leung, I Gruber, T |
| author_sort | Hanauer, T |
| collection | OXFORD |
| description | Chemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Our findings reveal the potential of using carboxycalixarene-based receptors to study epigenetic regulation. |
| first_indexed | 2024-03-07T06:26:46Z |
| format | Journal article |
| id | oxford-uuid:f491abfe-10ac-4aae-9493-178277dfb8fe |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:26:46Z |
| publishDate | 2017 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:f491abfe-10ac-4aae-9493-178277dfb8fe2022-03-27T12:20:52ZSelective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptorJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f491abfe-10ac-4aae-9493-178277dfb8feEnglishSymplectic Elements at OxfordRoyal Society of Chemistry2017Hanauer, THopkinson, RPatel, KLi, YCorreddu, DKawamura, ASarojini, VLeung, IGruber, TChemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Our findings reveal the potential of using carboxycalixarene-based receptors to study epigenetic regulation. |
| spellingShingle | Hanauer, T Hopkinson, R Patel, K Li, Y Correddu, D Kawamura, A Sarojini, V Leung, I Gruber, T Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor |
| title | Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor |
| title_full | Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor |
| title_fullStr | Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor |
| title_full_unstemmed | Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor |
| title_short | Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor |
| title_sort | selective recognition of the di trimethylammonium motif by an artificial carboxycalixarene receptor |
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