MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice.

MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice.

Glucocorticoid-induced osteoporosis (GCOP) is predominantly caused by inhibition of bone formation, resulting from a decrease in osteoblast numbers. Employing mouse (MBA-15.4) and human (MG-63) osteoblast cell lines, we previously found that the glucocorticoid (GC) dexamethasone (Dex) inhibits cellu...

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Bibliographic Details
Main Authors:	Conradie, M, Cato, A, Ferris, W, De Wet, H, Horsch, K, Hough, S
Format:	Journal article
Language:	English
Published:	2011

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