An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site

An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site

We have previously isolated nucleic acid ligands (aptamers) that bind the surface envelope glycoprotein, gp120, of HIV-1, and neutralize infection of diverse sub-types of virus. Our earlier studies have identified the overall structure of one of these aptamers, B40, and have indicated that it binds...

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Dades bibliogràfiques
Autors principals:	Cohen, C, James, W, Forzan, M, Sproat, B, Pantophlet, R, McGowan, I, Burton, D
Format:	Journal article
Idioma:	English
Publicat:	Elsevier 2008

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