Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

Solid malignancies have been speculated to depend on cancer stem cells (CSCs) for expansion and relapse after therapy. Here we report on quantitative analyses of lineage tracing data from primary colon cancer xenograft tissue to assess CSC functionality in a human solid malignancy. The temporally ob...

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Bibliographic Details
Main Authors: Lenos, K, Miedema, D, Lodestijn, S, Nijman, L, Van Den Bosch, T, Romero Ros, X, Lourenço, F, Lecca, M, Van Der Heijden, M, Van Neerven, S, Van Oort, A, Leveille, N, Adam, R, De Sousa E Melo, F, Otten, J, Veerman, P, Hypolite, G, Koens, L, Lyons, S, Stassi, G, Winton, D, Medema, J, Morrissey, E, Bijlsma, M, Vermeulen, L
Format: Journal article
Language:English
Published: Nature Research 2018

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