Genomic instability--the engine of tumorigenesis?

Genomic instability--the engine of tumorigenesis?

Human cancers harbour numerous mutations and it has been proposed that these result from some form of inherent genomic instability. Some cancers have proven genomic instability or features that are indicative of this. Inherited cancer syndromes exist that are caused by deficient DNA repair or chromo...

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Bibliografiske detaljer
Main Authors:	Sieber, O, Heinimann, K, Tomlinson, I
Format:	Journal article
Sprog:	English
Udgivet:	2003

Lignende værker

Genomic stability and tumorigenesis.
af: Sieber, O, et al.
Udgivet: (2005)

Genomic instability is an early event in aluminium-induced tumorigenesis
af: Mandriota, SJ, et al.
Udgivet: (2020)

Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy?
af: Sieber, O, et al.
Udgivet: (2003)

Mitochondrial genome instability: its potential role in biomarker discovery for brain tumorigenesis
af: Yusoff, Abdul Aziz Mohamed
Udgivet: (2017)

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.
af: Sieber, O, et al.
Udgivet: (2002)

Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.
af: Marie-Jo Halaby, et al.
Udgivet: (2013-01-01)

CIC protein instability contributes to tumorigenesis in glioblastoma
af: Severa Bunda, et al.
Udgivet: (2019-02-01)

Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis
af: Xiufang Xiong, et al.
Udgivet: (2014-08-01)

ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability.
af: Youssef Errami, et al.
Udgivet: (2013-01-01)

Towards a molecular classification of colorectal cancer:The role of microsatellite instability status
af: Karl eHeinimann
Udgivet: (2013-10-01)

CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability
af: Fangzhen Chen, et al.
Udgivet: (2023-09-01)

Genomic analysis of mouse tumorigenesis
af: Tam, Mandy Chi-Mun
Udgivet: (2007)

The evolutionary landscape of colorectal tumorigenesis
af: Cross, W, et al.
Udgivet: (2018)

A study of genomic instability in early preneoplastic colonic lesions
af: Beggs, A, et al.
Udgivet: (2013)

A study of genomic instability in early preneoplastic colonic lesions.
af: Beggs, A, et al.
Udgivet: (2013)

The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.
af: Pollard, P, et al.
Udgivet: (2003)

Kinesin-7 CENP-E in tumorigenesis: Chromosome instability, spindle assembly checkpoint, and applications
af: Yu-Hao Yang, et al.
Udgivet: (2024-03-01)

Chromosomal instability and tumorigenesis : genetic analysis of the murine spindle checkpoint gene Mps1
af: Xie, Stephanie Zhi-Juan
Udgivet: (2007)

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.
af: Sieber, O, et al.
Udgivet: (2004)

A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt.
af: d'Onofrio, A, et al.
Udgivet: (2007)

Chromosome 11q in sporadic colorectal carcinoma: patterns of allele loss and their significance for tumorigenesis.
af: Tomlinson, I, et al.
Udgivet: (1996)

Forest Road Network and Transportation Engineering – State and Perspectives
af: Hans Rudolf Heinimann
Udgivet: (2017-01-01)

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.
af: Crabtree, M, et al.
Udgivet: (2003)

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas.
af: Jones, A, et al.
Udgivet: (2007)

Forest operations engineering and management – the ways behind and ahead of a scientific discipline
af: Hans Rudolf Heinimann
Udgivet: (2007-01-01)

Forest operations engineering and management – the ways behind and ahead of a scientific discipline
af: Hans Rudolf Heinimann
Udgivet: (2007-03-01)

Tissue, cell and stage specificity of (epi)mutations in cancers.
af: Sieber, O, et al.
Udgivet: (2005)

Tumor Hypoxia Drives Genomic Instability
af: Ming Tang, et al.
Udgivet: (2021-03-01)

Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis
af: Gascoigne, Karen E., et al.
Udgivet: (2013)

Chromosomal instability, colorectal cancer and taxane resistance.
af: Swanton, C, et al.
Udgivet: (2006)

Instabilities and catastrophes in science and engineering/
af: 338930 Thompson, J. M. T.
Udgivet: (1982)

Instabilities and turbulence in engineering flows /
af: Ashpis, D. E., et al.
Udgivet: (1993)

Genomic instability and eye diseases
af: Hongyan Liu, et al.
Udgivet: (2023-08-01)

Editorial: Genomic Instability and Neurodegeneration
af: Julia Fuchs, et al.
Udgivet: (2022-06-01)

Genome instability in cancer development /
af: Nigg, Erich A.
Udgivet: (2005)

Genome instability and transgenerational effects /
af: Kovalchuk, Igor, et al.
Udgivet: (2010)

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.
af: Sieber, O, et al.
Udgivet: (2003)

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.
af: Peter C Scacheri, et al.
Udgivet: (2006-04-01)

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability.
af: Kemp, Z, et al.
Udgivet: (2005)

Attenuated familial adenomatous polyposis: results from an international collaborative study.
af: Knudsen, A, et al.
Udgivet: (2010)