Peptide-directed assembly of single-helical gold nanoparticle superstructures exhibiting intense chiroptical activity
Chiral nanoparticle assemblies are an interesting class of materials whose chiroptical properties make them attractive for a variety of applications. Here, C18-(PEPAu(M-ox))2 (PEPAu(M-ox) = AYSSGAPPM(ox)PPF) is shown to direct the assembly of single-helical gold nanoparticle superstructures that exh...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2016
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| _version_ | 1797104044900089856 |
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| author | Merg, A Boatz, J Mandal, A Zhao, G Mokashi-Punekar, S Liu, C Wang, X Zhang, P van der Wel, P Rosi, N |
| author_facet | Merg, A Boatz, J Mandal, A Zhao, G Mokashi-Punekar, S Liu, C Wang, X Zhang, P van der Wel, P Rosi, N |
| author_sort | Merg, A |
| collection | OXFORD |
| description | Chiral nanoparticle assemblies are an interesting class of materials whose chiroptical properties make them attractive for a variety of applications. Here, C18-(PEPAu(M-ox))2 (PEPAu(M-ox) = AYSSGAPPM(ox)PPF) is shown to direct the assembly of single-helical gold nanoparticle superstructures that exhibit exceptionally strong chiroptical activity at the plasmon frequency with absolute g-factor values up to 0.04. Transmission electron microscopy (TEM) and cryogenic electron tomography (cryo-ET) results indicate that the single helices have a periodic pitch of approximately 100 nm and consist of oblong gold nanoparticles. The morphology and assembled structure of C18-(PEPAu(M-ox))2 are studied using TEM, atomic force microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy, circular dichroism (CD) spectroscopy, X-ray diffraction (XRD), and solid-state nuclear magnetic resonance (ssNMR) spectroscopy. TEM and AFM reveal that C18-(PEPAu(M-ox))2 assembles into linear amyloid-like 1D helical ribbons having structural parameters that correlate to those of the single-helical gold nanoparticle superstructures. FTIR, CD, XRD, and ssNMR indicate the presence of cross-β and polyproline II secondary structures. A molecular assembly model is presented that takes into account all experimental observations and that supports the single-helical nanoparticle assembly architecture. This model provides the basis for the design of future nanoparticle assemblies having programmable structures and properties. |
| first_indexed | 2024-03-07T06:28:19Z |
| format | Journal article |
| id | oxford-uuid:f517b04e-a022-48c3-afc9-32a690ea15ff |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:28:19Z |
| publishDate | 2016 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:f517b04e-a022-48c3-afc9-32a690ea15ff2022-03-27T12:24:43ZPeptide-directed assembly of single-helical gold nanoparticle superstructures exhibiting intense chiroptical activityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f517b04e-a022-48c3-afc9-32a690ea15ffEnglishSymplectic Elements at OxfordAmerican Chemical Society2016Merg, ABoatz, JMandal, AZhao, GMokashi-Punekar, SLiu, CWang, XZhang, Pvan der Wel, PRosi, NChiral nanoparticle assemblies are an interesting class of materials whose chiroptical properties make them attractive for a variety of applications. Here, C18-(PEPAu(M-ox))2 (PEPAu(M-ox) = AYSSGAPPM(ox)PPF) is shown to direct the assembly of single-helical gold nanoparticle superstructures that exhibit exceptionally strong chiroptical activity at the plasmon frequency with absolute g-factor values up to 0.04. Transmission electron microscopy (TEM) and cryogenic electron tomography (cryo-ET) results indicate that the single helices have a periodic pitch of approximately 100 nm and consist of oblong gold nanoparticles. The morphology and assembled structure of C18-(PEPAu(M-ox))2 are studied using TEM, atomic force microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy, circular dichroism (CD) spectroscopy, X-ray diffraction (XRD), and solid-state nuclear magnetic resonance (ssNMR) spectroscopy. TEM and AFM reveal that C18-(PEPAu(M-ox))2 assembles into linear amyloid-like 1D helical ribbons having structural parameters that correlate to those of the single-helical gold nanoparticle superstructures. FTIR, CD, XRD, and ssNMR indicate the presence of cross-β and polyproline II secondary structures. A molecular assembly model is presented that takes into account all experimental observations and that supports the single-helical nanoparticle assembly architecture. This model provides the basis for the design of future nanoparticle assemblies having programmable structures and properties. |
| spellingShingle | Merg, A Boatz, J Mandal, A Zhao, G Mokashi-Punekar, S Liu, C Wang, X Zhang, P van der Wel, P Rosi, N Peptide-directed assembly of single-helical gold nanoparticle superstructures exhibiting intense chiroptical activity |
| title | Peptide-directed assembly of single-helical gold nanoparticle superstructures exhibiting intense chiroptical activity |
| title_full | Peptide-directed assembly of single-helical gold nanoparticle superstructures exhibiting intense chiroptical activity |
| title_fullStr | Peptide-directed assembly of single-helical gold nanoparticle superstructures exhibiting intense chiroptical activity |
| title_full_unstemmed | Peptide-directed assembly of single-helical gold nanoparticle superstructures exhibiting intense chiroptical activity |
| title_short | Peptide-directed assembly of single-helical gold nanoparticle superstructures exhibiting intense chiroptical activity |
| title_sort | peptide directed assembly of single helical gold nanoparticle superstructures exhibiting intense chiroptical activity |
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