Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network
Oscillations are crucial to the normal function of living organisms, across a wide variety of biological processes. In eukaryotes, oscillatory dynamics are thought to arise from interactions at the protein and RNA levels; however, the role of non-coding RNA in regulating these dynamics remains under...
| Autors principals: | , , , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
Elsevier
2018
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| _version_ | 1826305148325986304 |
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| author | Dhawan, A Harris, AL Buffa, FM Scott, JG |
| author_facet | Dhawan, A Harris, AL Buffa, FM Scott, JG |
| author_sort | Dhawan, A |
| collection | OXFORD |
| description | Oscillations are crucial to the normal function of living organisms, across a wide variety of biological processes. In eukaryotes, oscillatory dynamics are thought to arise from interactions at the protein and RNA levels; however, the role of non-coding RNA in regulating these dynamics remains understudied. In this work, we show how non-coding RNA acting as microRNA (miRNA) sponges in a conserved miRNA - transcription factor feedback motif, can give rise to oscillatory behaviour, and how to test for this experimentally. Control of these non-coding RNA can dynamically create oscillations or stability, and we show how this behaviour predisposes to oscillations in the stochastic limit. These results, supported by emerging evidence for the role of miRNA sponges in development, point towards key roles of different species of miRNA sponges, such as circular RNA, potentially in the maintenance of yet unexplained oscillatory behaviour. These results help to provide a paradigm for understanding functional differences between the many redundant, but distinct RNA species thought to act as miRNA sponges in nature, such as long non-coding RNA, pseudogenes, competing mRNA, circular RNA, and3′ UTRs. |
| first_indexed | 2024-03-07T06:28:28Z |
| format | Journal article |
| id | oxford-uuid:f5244c3b-6aee-4d01-9281-52e7e39359cf |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:28:28Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:f5244c3b-6aee-4d01-9281-52e7e39359cf2022-03-27T12:25:06ZEndogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA networkJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f5244c3b-6aee-4d01-9281-52e7e39359cfEnglishSymplectic Elements at OxfordElsevier2018Dhawan, AHarris, ALBuffa, FMScott, JGOscillations are crucial to the normal function of living organisms, across a wide variety of biological processes. In eukaryotes, oscillatory dynamics are thought to arise from interactions at the protein and RNA levels; however, the role of non-coding RNA in regulating these dynamics remains understudied. In this work, we show how non-coding RNA acting as microRNA (miRNA) sponges in a conserved miRNA - transcription factor feedback motif, can give rise to oscillatory behaviour, and how to test for this experimentally. Control of these non-coding RNA can dynamically create oscillations or stability, and we show how this behaviour predisposes to oscillations in the stochastic limit. These results, supported by emerging evidence for the role of miRNA sponges in development, point towards key roles of different species of miRNA sponges, such as circular RNA, potentially in the maintenance of yet unexplained oscillatory behaviour. These results help to provide a paradigm for understanding functional differences between the many redundant, but distinct RNA species thought to act as miRNA sponges in nature, such as long non-coding RNA, pseudogenes, competing mRNA, circular RNA, and3′ UTRs. |
| spellingShingle | Dhawan, A Harris, AL Buffa, FM Scott, JG Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network |
| title | Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network |
| title_full | Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network |
| title_fullStr | Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network |
| title_full_unstemmed | Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network |
| title_short | Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network |
| title_sort | endogenous mirna sponges mediate the generation of oscillatory dynamics for a non coding rna network |
| work_keys_str_mv | AT dhawana endogenousmirnaspongesmediatethegenerationofoscillatorydynamicsforanoncodingrnanetwork AT harrisal endogenousmirnaspongesmediatethegenerationofoscillatorydynamicsforanoncodingrnanetwork AT buffafm endogenousmirnaspongesmediatethegenerationofoscillatorydynamicsforanoncodingrnanetwork AT scottjg endogenousmirnaspongesmediatethegenerationofoscillatorydynamicsforanoncodingrnanetwork |