T cell responses are governed by avidity and co-stimulatory thresholds.
We analyzed the avidity and CD28-mediated co-stimulatory requirements for the activation of T cells in vivo and in vitro. The strength of the T cell/antigen-presenting cell interaction was varied by using altered peptide ligands for stimulation. Co-stimulatory requirements were studied using T cells...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1996
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| _version_ | 1797104070942523392 |
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| author | Bachmann, M Sebzda, E Kündig, T Shahinian, A Speiser, D Mak, T Ohashi, P |
| author_facet | Bachmann, M Sebzda, E Kündig, T Shahinian, A Speiser, D Mak, T Ohashi, P |
| author_sort | Bachmann, M |
| collection | OXFORD |
| description | We analyzed the avidity and CD28-mediated co-stimulatory requirements for the activation of T cells in vivo and in vitro. The strength of the T cell/antigen-presenting cell interaction was varied by using altered peptide ligands for stimulation. Co-stimulatory requirements were studied using T cells from CD28-deficient mice. The results indicate that T cell activation is not an all-or-nothing event, but occurs in distinct steps. For each step, a certain avidity, co-stimulatory threshold or both, must be met. Depending upon the strength of the interaction between the T cell receptor and the major histocompatibility complex/peptide and the presence of CD28 co-stimulatory signals, T cells may undergo blast formation alone or proliferate or eventually both proliferate and differentiate to effector cells. Thus, T cell activation is governed by both avidity and co-stimulatory thresholds. |
| first_indexed | 2024-03-07T06:28:37Z |
| format | Journal article |
| id | oxford-uuid:f52d4710-a0e1-4b77-99ce-6613444eb101 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:28:37Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:f52d4710-a0e1-4b77-99ce-6613444eb1012022-03-27T12:25:26ZT cell responses are governed by avidity and co-stimulatory thresholds.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f52d4710-a0e1-4b77-99ce-6613444eb101EnglishSymplectic Elements at Oxford1996Bachmann, MSebzda, EKündig, TShahinian, ASpeiser, DMak, TOhashi, PWe analyzed the avidity and CD28-mediated co-stimulatory requirements for the activation of T cells in vivo and in vitro. The strength of the T cell/antigen-presenting cell interaction was varied by using altered peptide ligands for stimulation. Co-stimulatory requirements were studied using T cells from CD28-deficient mice. The results indicate that T cell activation is not an all-or-nothing event, but occurs in distinct steps. For each step, a certain avidity, co-stimulatory threshold or both, must be met. Depending upon the strength of the interaction between the T cell receptor and the major histocompatibility complex/peptide and the presence of CD28 co-stimulatory signals, T cells may undergo blast formation alone or proliferate or eventually both proliferate and differentiate to effector cells. Thus, T cell activation is governed by both avidity and co-stimulatory thresholds. |
| spellingShingle | Bachmann, M Sebzda, E Kündig, T Shahinian, A Speiser, D Mak, T Ohashi, P T cell responses are governed by avidity and co-stimulatory thresholds. |
| title | T cell responses are governed by avidity and co-stimulatory thresholds. |
| title_full | T cell responses are governed by avidity and co-stimulatory thresholds. |
| title_fullStr | T cell responses are governed by avidity and co-stimulatory thresholds. |
| title_full_unstemmed | T cell responses are governed by avidity and co-stimulatory thresholds. |
| title_short | T cell responses are governed by avidity and co-stimulatory thresholds. |
| title_sort | t cell responses are governed by avidity and co stimulatory thresholds |
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