Texture‐based morphometry in relation to apolipoprotein ε4 genotype, ageing and sex in a midlife population
Brain atrophy and cortical thinning are typically observed in people with Alzheimer's disease (AD) and, to a lesser extent, in those with mild cognitive impairment. In asymptomatic middle‐aged apolipoprotein ε4 (ΑPOE4) carriers, who are at higher risk of future AD, study reports are discordant...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Wiley Open Access
2024
|
| _version_ | 1811140498068340736 |
|---|---|
| author | Dounavi, M Mak, E Operto, G Muniz‐Terrera, G Bridgeman, K Koychev, I Malhotra, P Naci, L Lawlor, B Su, L Falcon, C Ritchie, K Ritchie, CW Gispert, JD O'Brien, JT |
| author_facet | Dounavi, M Mak, E Operto, G Muniz‐Terrera, G Bridgeman, K Koychev, I Malhotra, P Naci, L Lawlor, B Su, L Falcon, C Ritchie, K Ritchie, CW Gispert, JD O'Brien, JT |
| author_sort | Dounavi, M |
| collection | OXFORD |
| description | Brain atrophy and cortical thinning are typically observed in people with Alzheimer's disease (AD) and, to a lesser extent, in those with mild cognitive impairment. In asymptomatic middle‐aged apolipoprotein ε4 (ΑPOE4) carriers, who are at higher risk of future AD, study reports are discordant with limited evidence of brain structural differences between carriers and non‐carriers of the ε4 allele. Alternative imaging markers with higher sensitivity at the presymptomatic stage, ideally quantified using typically acquired structural MRI scans, would thus be of great benefit for the detection of early disease, disease monitoring and subject stratification. In the present cross‐sectional study, we investigated textural properties of T1‐weighted 3T MRI scans in relation to APOE4 genotype, age and sex. We pooled together data from the PREVENT‐Dementia and ALFA studies focused on midlife healthy populations with dementia risk factors (analysable cohort: 1585 participants; mean age 56.2 ± 7.4 years). Voxel‐based and texture (examined features: contrast, entropy, energy, homogeneity) based morphometry was used to identify areas of volumetric and textural differences between APOE4 carriers and non‐carriers. Textural maps were generated and were subsequently harmonised using voxel‐wise COMBAT. For all analyses, APOE4, sex, age and years of education were used as model predictors. Interactions between APOE4 and age were further examined. There were no group differences in regional brain volume or texture based on APOE4 carriership or when age × APOE4 interactions were examined. Older people tended to have a less homogeneous textural profile in grey and white matter and a more homogeneous profile in the ventricles. A more heterogeneous textural profile was observed for females in areas such as the ventricles, frontal and parietal lobes and for males in the brainstem, cerebellum, precuneus and cingulate. Overall, we have shown the absence of volumetric and textural differences between APOE4 carriers and non‐carriers at midlife and have established associations of textural features with ageing and sex. |
| first_indexed | 2024-09-25T04:22:56Z |
| format | Journal article |
| id | oxford-uuid:f533cfdd-dd3a-44a4-9da7-b6d36b909485 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:22:56Z |
| publishDate | 2024 |
| publisher | Wiley Open Access |
| record_format | dspace |
| spelling | oxford-uuid:f533cfdd-dd3a-44a4-9da7-b6d36b9094852024-08-14T20:07:09ZTexture‐based morphometry in relation to apolipoprotein ε4 genotype, ageing and sex in a midlife populationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f533cfdd-dd3a-44a4-9da7-b6d36b909485EnglishJisc Publications RouterWiley Open Access2024Dounavi, MMak, EOperto, GMuniz‐Terrera, GBridgeman, KKoychev, IMalhotra, PNaci, LLawlor, BSu, LFalcon, CRitchie, KRitchie, CWGispert, JDO'Brien, JTBrain atrophy and cortical thinning are typically observed in people with Alzheimer's disease (AD) and, to a lesser extent, in those with mild cognitive impairment. In asymptomatic middle‐aged apolipoprotein ε4 (ΑPOE4) carriers, who are at higher risk of future AD, study reports are discordant with limited evidence of brain structural differences between carriers and non‐carriers of the ε4 allele. Alternative imaging markers with higher sensitivity at the presymptomatic stage, ideally quantified using typically acquired structural MRI scans, would thus be of great benefit for the detection of early disease, disease monitoring and subject stratification. In the present cross‐sectional study, we investigated textural properties of T1‐weighted 3T MRI scans in relation to APOE4 genotype, age and sex. We pooled together data from the PREVENT‐Dementia and ALFA studies focused on midlife healthy populations with dementia risk factors (analysable cohort: 1585 participants; mean age 56.2 ± 7.4 years). Voxel‐based and texture (examined features: contrast, entropy, energy, homogeneity) based morphometry was used to identify areas of volumetric and textural differences between APOE4 carriers and non‐carriers. Textural maps were generated and were subsequently harmonised using voxel‐wise COMBAT. For all analyses, APOE4, sex, age and years of education were used as model predictors. Interactions between APOE4 and age were further examined. There were no group differences in regional brain volume or texture based on APOE4 carriership or when age × APOE4 interactions were examined. Older people tended to have a less homogeneous textural profile in grey and white matter and a more homogeneous profile in the ventricles. A more heterogeneous textural profile was observed for females in areas such as the ventricles, frontal and parietal lobes and for males in the brainstem, cerebellum, precuneus and cingulate. Overall, we have shown the absence of volumetric and textural differences between APOE4 carriers and non‐carriers at midlife and have established associations of textural features with ageing and sex. |
| spellingShingle | Dounavi, M Mak, E Operto, G Muniz‐Terrera, G Bridgeman, K Koychev, I Malhotra, P Naci, L Lawlor, B Su, L Falcon, C Ritchie, K Ritchie, CW Gispert, JD O'Brien, JT Texture‐based morphometry in relation to apolipoprotein ε4 genotype, ageing and sex in a midlife population |
| title | Texture‐based morphometry in relation to apolipoprotein ε4 genotype, ageing and sex in a midlife population |
| title_full | Texture‐based morphometry in relation to apolipoprotein ε4 genotype, ageing and sex in a midlife population |
| title_fullStr | Texture‐based morphometry in relation to apolipoprotein ε4 genotype, ageing and sex in a midlife population |
| title_full_unstemmed | Texture‐based morphometry in relation to apolipoprotein ε4 genotype, ageing and sex in a midlife population |
| title_short | Texture‐based morphometry in relation to apolipoprotein ε4 genotype, ageing and sex in a midlife population |
| title_sort | texture based morphometry in relation to apolipoprotein ε4 genotype ageing and sex in a midlife population |
| work_keys_str_mv | AT dounavim texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT make texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT opertog texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT munizterrerag texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT bridgemank texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT koychevi texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT malhotrap texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT nacil texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT lawlorb texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT sul texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT falconc texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT ritchiek texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT ritchiecw texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT gispertjd texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation AT obrienjt texturebasedmorphometryinrelationtoapolipoproteine4genotypeageingandsexinamidlifepopulation |