Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.

Hemolysis drives susceptibility to bacterial infections and predicts poor outcome from sepsis. These detrimental effects are commonly considered a consequence of heme-iron serving as a nutrient for bacteria. Here, we employed a Gram-negative sepsis model and found that elevated heme levels impaired...

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Detalhes bibliográficos
Main Authors:	Martins, R, Maier, J, Gorki, A, Huber, K, Sharif, O, Starkl, P, Saluzzo, S, Quattrone, F, Gawish, R, Lakovits, K, Aichinger, M, Radic-Sarikas, B, Lardeau, C, Hladik, A, Korosec, A, Brown, M, Vaahtomeri, K, Duggan, M, Kerjaschki, D, Esterbauer, H, Colinge, J, Eisenbarth, S, Decker, T, Bennett, K, Kubicek, S, Sixt, M, Superti-Furga, G, Knapp, S
Formato:	Journal article
Idioma:	English
Publicado em:	Nature Publishing Group 2016

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.

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