LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression
RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5′-terminal oligopyrimidine tract (TOP) mRNA translation. Here, we show that LARP1 is co...
| Autors principals: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Publicat: |
Nature Publishing Group: Open Access Hybrid Model Option B
2015
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| _version_ | 1826305166860615680 |
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| author | Blagden, S Bushell, M Willis, A Mura, M Hopkins, T Michael, T Abd-Latip, N Curry, E Weir, J Aboagye, E Sturge, J Jameson, C Mauri, F |
| author_facet | Blagden, S Bushell, M Willis, A Mura, M Hopkins, T Michael, T Abd-Latip, N Curry, E Weir, J Aboagye, E Sturge, J Jameson, C Mauri, F |
| author_sort | Blagden, S |
| collection | OXFORD |
| description | RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5′-terminal oligopyrimidine tract (TOP) mRNA translation. Here, we show that LARP1 is complexed to 3000 mRNAs enriched for cancer pathways. A prominent member of the LARP1 interactome is mTOR whose mRNA transcript is stabilized by LARP1. At a functional level, we show that LARP1 promotes cell migration, invasion, anchorage-independent growth and in vivo tumorigenesis. Furthermore, we show that LARP1 expression is elevated in epithelial cancers such as cervical and non-small cell lung cancers, where its expression correlates with disease progression and adverse prognosis, respectively. We therefore conclude that, through the post-transcriptional regulation of genes such as mTOR within cancer pathways, LARP1 contributes to cancer progression. |
| first_indexed | 2024-03-07T06:28:46Z |
| format | Journal article |
| id | oxford-uuid:f53acfee-8c6b-4289-9814-db3db9a1def5 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T06:28:46Z |
| publishDate | 2015 |
| publisher | Nature Publishing Group: Open Access Hybrid Model Option B |
| record_format | dspace |
| spelling | oxford-uuid:f53acfee-8c6b-4289-9814-db3db9a1def52022-03-27T12:25:48ZLARP1 post-transcriptionally regulates mTOR and contributes to cancer progressionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f53acfee-8c6b-4289-9814-db3db9a1def5Symplectic Elements at OxfordNature Publishing Group: Open Access Hybrid Model Option B2015Blagden, SBushell, MWillis, AMura, MHopkins, TMichael, TAbd-Latip, NCurry, EWeir, JAboagye, ESturge, JJameson, CMauri, FRNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5′-terminal oligopyrimidine tract (TOP) mRNA translation. Here, we show that LARP1 is complexed to 3000 mRNAs enriched for cancer pathways. A prominent member of the LARP1 interactome is mTOR whose mRNA transcript is stabilized by LARP1. At a functional level, we show that LARP1 promotes cell migration, invasion, anchorage-independent growth and in vivo tumorigenesis. Furthermore, we show that LARP1 expression is elevated in epithelial cancers such as cervical and non-small cell lung cancers, where its expression correlates with disease progression and adverse prognosis, respectively. We therefore conclude that, through the post-transcriptional regulation of genes such as mTOR within cancer pathways, LARP1 contributes to cancer progression. |
| spellingShingle | Blagden, S Bushell, M Willis, A Mura, M Hopkins, T Michael, T Abd-Latip, N Curry, E Weir, J Aboagye, E Sturge, J Jameson, C Mauri, F LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression |
| title | LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression |
| title_full | LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression |
| title_fullStr | LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression |
| title_full_unstemmed | LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression |
| title_short | LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression |
| title_sort | larp1 post transcriptionally regulates mtor and contributes to cancer progression |
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