Factor inhibiting HIF can catalyse two asparaginyl-hydroxylations in VNVN motifs of ankyrin fold proteins

The aspariginyl-hydroxylase human Factor Inhibiting HIF (FIH) is an important regulator of the transcriptional activity of hypoxia inducible factor (HIF). FIH also catalyses the hydroxylation of asparaginyl and other residues in ankyrin repeat domain (ARD) containing proteins, including apoptosis st...

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Detalhes bibliográficos
Principais autores: Leissing, TM, Hardy, AP, Chan, H, Wang, Y, Tumber, A, Chowdhury, R, Fang, P, Coleman, ML, Cockman, ME, Kramer, HB, Berridge, G, Fischer, R, Kessler, B, Ratcliffe, PJ, Lu, X, Schofield, CJ
Formato: Journal article
Idioma:English
Publicado em: Elsevier 2022