Inhibition of protein crystallization by evolutionary negative design.
Why are proteins so hard to crystallize? We propose an 'evolutionary negative design' principle to explain this difficulty. Proteins have evolved to avoid crystallization because crystallization compromises the viability of the cell. Evolutionary negative design is supported by much eviden...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
IOP Publishing
2004
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| _version_ | 1797104111224619008 |
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| author | Doye, J Louis, A Vendruscolo, M |
| author_facet | Doye, J Louis, A Vendruscolo, M |
| author_sort | Doye, J |
| collection | OXFORD |
| description | Why are proteins so hard to crystallize? We propose an 'evolutionary negative design' principle to explain this difficulty. Proteins have evolved to avoid crystallization because crystallization compromises the viability of the cell. Evolutionary negative design is supported by much evidence in the literature, including the effect of mutations on the crystallizability of a protein, the correlations found in the properties of crystal contacts in bioinformatics databases, and the positive use of protein crystallization by bacteria and viruses. |
| first_indexed | 2024-03-07T06:29:12Z |
| format | Journal article |
| id | oxford-uuid:f56300a3-6b58-477e-ac33-736f186ed779 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:29:12Z |
| publishDate | 2004 |
| publisher | IOP Publishing |
| record_format | dspace |
| spelling | oxford-uuid:f56300a3-6b58-477e-ac33-736f186ed7792022-03-27T12:26:59ZInhibition of protein crystallization by evolutionary negative design.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f56300a3-6b58-477e-ac33-736f186ed779EnglishSymplectic Elements at OxfordIOP Publishing2004Doye, JLouis, AVendruscolo, MWhy are proteins so hard to crystallize? We propose an 'evolutionary negative design' principle to explain this difficulty. Proteins have evolved to avoid crystallization because crystallization compromises the viability of the cell. Evolutionary negative design is supported by much evidence in the literature, including the effect of mutations on the crystallizability of a protein, the correlations found in the properties of crystal contacts in bioinformatics databases, and the positive use of protein crystallization by bacteria and viruses. |
| spellingShingle | Doye, J Louis, A Vendruscolo, M Inhibition of protein crystallization by evolutionary negative design. |
| title | Inhibition of protein crystallization by evolutionary negative design. |
| title_full | Inhibition of protein crystallization by evolutionary negative design. |
| title_fullStr | Inhibition of protein crystallization by evolutionary negative design. |
| title_full_unstemmed | Inhibition of protein crystallization by evolutionary negative design. |
| title_short | Inhibition of protein crystallization by evolutionary negative design. |
| title_sort | inhibition of protein crystallization by evolutionary negative design |
| work_keys_str_mv | AT doyej inhibitionofproteincrystallizationbyevolutionarynegativedesign AT louisa inhibitionofproteincrystallizationbyevolutionarynegativedesign AT vendruscolom inhibitionofproteincrystallizationbyevolutionarynegativedesign |