Inhibition of protein crystallization by evolutionary negative design.
Why are proteins so hard to crystallize? We propose an 'evolutionary negative design' principle to explain this difficulty. Proteins have evolved to avoid crystallization because crystallization compromises the viability of the cell. Evolutionary negative design is supported by much eviden...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
IOP Publishing
2004
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