Confocal single-molecule fluorescence as a tool for investigating biomolecular dynamics in vitro and in vivo

Confocal single-molecule fluorescence as a tool for investigating biomolecular dynamics in vitro and in vivo

<p>Confocal single-molecule fluorescence is a powerful tool for monitoring conformational dynamics, and has provided new insight into the enzymatic activities of complex biological molecules such as DNA and RNA polymerases. Though useful, such studies are typically qualitative in nature, and p...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Torella, J, Joseph Peter Torella
Andre forfattere:	Kapanidis, A
Format:	Thesis
Sprog:	English
Udgivet:	2011
Fag:	Mathematical biology Cell Biology (see also Plant sciences) Condensed Matter Physics Stochastic processes Biophysics Life Sciences Biosensors Enzymes Probability theory and stochastic processes Molecular biophysics (biochemistry) Microscopy Biochemistry Biology Spectroscopy and molecular structure Chemical kinetics

Lignende værker

Mechanisms of transcription regulation by full-length CREB
af: Jeremie Gaudez
Udgivet: (2023)

Single-molecule imaging of electroporated chemotaxis proteins in live bacteria
af: Di Paolo, D
Udgivet: (2015)

Fluorescence studies of influenza RNA and RNA polymerase
af: Tomescu, A
Udgivet: (2014)

Ion channels: a first view of K⁺ channels in atomic glory
af: Sansom, M
Udgivet: (1998)

Mass Photometry of Membrane Proteins
af: Olerinyova, A, et al.
Udgivet: (2020)

Adapting nanobody scaffolds as protein chaperones for effective crystallization and good protein behaviour in cryo-EM
af: Ye, M
Udgivet: (2021)

Physical biology : from atoms to medicine /
af: Zewail, Ahmed
Udgivet: (2008)

Structural and functional studies of chromatin modifying enzymes
af: Walport, L
Udgivet: (2013)

Structural and functional studies of C-nucleoside formation enzymes
af: Li, W
Udgivet: (2023)

Combined effects of double mutations on catalytic activity and structural stability contribute to clinical manifestations of glucose-6-phosphate dehydrogenase deficiency
af: Pakparnich, P, et al.
Udgivet: (2021)

Electrical interactions in molecular biophysics : an introduction/
af: 421226 Gabler, Raymond
Udgivet: (1978)

Bioelectrochemistry by fluorescent cyclic voltammetry
af: Mizzon, G
Udgivet: (2012)

Investigating the role of lipids and small-molecule ligands in hedgehog signalling using molecular dynamics simulations
af: Ansell, T
Udgivet: (2022)

Molecular dynamics study of water and Na⁺ ions in models of the pore region of the nicotinic acetylcholine receptor
af: Smith, G, et al.
Udgivet: (1997)

Structural studies of a membrane embedded chloride channel from E.Coli, a prokaryotic homologue of ClC channels
af: Bowler, M, et al.
Udgivet: (2001)

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues
af: Labro, A, et al.
Udgivet: (2008)

Interactions of Neisseria meningitidis with the human immune system
af: Harding, R
Udgivet: (2015)

Biophysical studies of membrane protein structure and function
af: Dijkman, P, et al.
Udgivet: (2014)

Radiation damage in protein crystals examined under various conditions by different methods
af: Garman, E, et al.
Udgivet: (2009)

Biophysical and magnetic resonance studies of membrane proteins
af: Orwick, M, et al.
Udgivet: (2011)

Determination of X-ray flux using silicon pin diodes
af: Owen, R, et al.
Udgivet: (2009)

The regulation and inhibition of P-TEFb
af: Hole, A
Udgivet: (2011)

Ion channels: structure of a molecular brake
af: Sansom, M
Udgivet: (1999)

The relationship between flagellar motor dynamics and the proton motive force
af: Tipping, M, et al.
Udgivet: (2011)

The dielectric properties of water within model transbilayer pores
af: Sansom, M, et al.
Udgivet: (1997)

The molecular basis for ER tubule formation
af: Brady, J
Udgivet: (2015)

A biophysical study of the G protein coupled receptor neurotensin receptor 1
af: Harding, PJ
Udgivet: (2007)

Control of the unidirectional motor in Rhodobacter sphaeroides
af: Brown, MT
Udgivet: (2009)

Structural characterisation of the interaction between Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) and their human ligands in severe malaria
af: Ng, HK
Udgivet: (2012)

Structural, biochemical and computational studies of TRP channel transmembrane domain modularity
af: Hanson, S
Udgivet: (2014)

Structure-function studies of the bacterial dsDNA translocase FtsK
af: Graham, JE
Udgivet: (2010)

Molecular and structural characterisation of the human Fibrillin-1 N-C terminal interaction
af: Yadin, D
Udgivet: (2013)

Application of magnetic torque on the bacterial flagellar motor
af: Lim, R
Udgivet: (2015)

Pushing the boundaries: molecular dynamics simulations of complex biological membranes
af: Parton, D
Udgivet: (2011)

Substrate recognition by the proteasome
af: Boehringer, J
Udgivet: (2011)

Single-molecule DNA sensors and cages for transcription factors in vitro and in vivo
af: Crawford, R
Udgivet: (2011)

Single molecule studies of a voltage-gated potassium channel
af: Angué, L
Udgivet: (2013)

Studying marcomolecular transitions by NMR and computer simulations
af: Stelzl, LS
Udgivet: (2014)

Real-time single-molecule observations of conformational changes in DNA polymerase
af: Evans, GW
Udgivet: (2013)

Stochastic modelling of the cell cycle
af: He, E
Udgivet: (2012)