Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil.

Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil.

ATP-sensitive K-channels (K(ATP) channels) are the target for K(ATP)-channel openers (KCOs), such as pinacidil and P1075. These channels are formed from pore-forming Kir6.2 and regulatory sulfonylurea receptors (SUR2A in heart and skeletal muscle; SUR2B in smooth muscle). The two isoforms of SUR2 di...

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Xehetasun bibliografikoak
Egile Nagusiak:	Reimann, F, Gribble, F, Ashcroft, F
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2000

Antzeko izenburuak

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The Kir6.2-F333I mutation differentially modulates K-ATP channels composed of SUR1 or SUR2 subunits
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The Kir6.2-F333I mutation differentially modulates K ATP channels composed of SUR1 and SUR2 subunits
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Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.
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MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
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Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1.
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A universally conserved residue in the SUR1 subunit of the K ATP channel is essential for translating nucleotide binding at SUR1 into channel opening
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Interaction of MgATP with the sulphonylurea subunit activates ATP sensitive K-channels receptor
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Interactions between tolbutamide and nucleotides on cloned K-ATP channels.
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ATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit.
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Thiol reagents and ATP do not interact with C717 in the SUR1 subunit of the beta-cell K-ATP channel
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The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide.
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Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.
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The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.
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A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.
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Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits.
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A model for regulation of the beta-cell ATP-sensitive K+-channel by nucleotides and diazoxide.
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Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain.
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Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.
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Glimepiride block of Kir6.2/SUR1 Kir6.2/SUR2A and Kir6.2/SUR2A and Kir6.2/SUR2B K-ATP channels.
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The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits.
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The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation.
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Time-dependent activation of Kir6.2/SUR2A channels but not Kir6.2/SUR1 channels in the presence of ATP
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Correlating structure and function in ATP-sensitive K+ channels.
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A novel SUR1/Kir6.2 specific K-ATP channel opener
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Time-dependent activation of KIR6.2/SUR2A channels but not KIR6.2/SUR1 channels in the presence of MgATP
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New windows on the mechanism of action of K(ATP) channel openers.
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A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening.
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ATP-sensitive K+ channels and insulin secretion: their role in health and disease.
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Differential metabolic and nucleotide sensitivity of beta-cell and cardiac K-ATP channels
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Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.
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Phentolamine block of ATP-sensitive K+ channels does not involve interaction with the sulphonylurea receptor, SUR1.
nork: Proks, P, et al.
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Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels.
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Screening for mutations in the Kir6.2 subunit of the beta-cell K-ATP channel
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