Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil.

Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil.

ATP-sensitive K-channels (K(ATP) channels) are the target for K(ATP)-channel openers (KCOs), such as pinacidil and P1075. These channels are formed from pore-forming Kir6.2 and regulatory sulfonylurea receptors (SUR2A in heart and skeletal muscle; SUR2B in smooth muscle). The two isoforms of SUR2 di...

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Autors principals:	Reimann, F, Gribble, F, Ashcroft, F
Format:	Journal article
Idioma:	English
Publicat:	2000

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