Cardiac magnetic resonance spectroscopy.
This review describes recent advances in cardiac magnetic resonance spectroscopy (MRS). MRS allows noninvasive characterization of the metabolic state of cardiac muscle, in both animal and human models. Recent experimental MRS studies have allowed new insights into the essential role of energetics i...
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1797104206001209344 |
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| author | Neubauer, S |
| author_facet | Neubauer, S |
| author_sort | Neubauer, S |
| collection | OXFORD |
| description | This review describes recent advances in cardiac magnetic resonance spectroscopy (MRS). MRS allows noninvasive characterization of the metabolic state of cardiac muscle, in both animal and human models. Recent experimental MRS studies have allowed new insights into the essential role of energetics in heart failure. Various new studies suggest a rapidly growing role of MRS for phenotyping new genetically modified mouse models, and recent methodologic advances include development of absolute quantification of high-energy phosphates, measurement of ATP turnover rates and thermodynamic parameters (such as free ADP and free energy change of ATP hydrolysis), and improved acquisition sequences. New patient studies demonstrate the potential value of MRS as a clinical diagnostic tool in patients with ischemic heart disease, heart failure, cardiac transplantation, valve disease, and genetic cardiomyopathy. |
| first_indexed | 2024-03-07T06:30:35Z |
| format | Journal article |
| id | oxford-uuid:f5dc6421-3688-4e55-8f2a-8a469735870a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:30:35Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:f5dc6421-3688-4e55-8f2a-8a469735870a2022-03-27T12:30:28ZCardiac magnetic resonance spectroscopy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f5dc6421-3688-4e55-8f2a-8a469735870aEnglishSymplectic Elements at Oxford2003Neubauer, SThis review describes recent advances in cardiac magnetic resonance spectroscopy (MRS). MRS allows noninvasive characterization of the metabolic state of cardiac muscle, in both animal and human models. Recent experimental MRS studies have allowed new insights into the essential role of energetics in heart failure. Various new studies suggest a rapidly growing role of MRS for phenotyping new genetically modified mouse models, and recent methodologic advances include development of absolute quantification of high-energy phosphates, measurement of ATP turnover rates and thermodynamic parameters (such as free ADP and free energy change of ATP hydrolysis), and improved acquisition sequences. New patient studies demonstrate the potential value of MRS as a clinical diagnostic tool in patients with ischemic heart disease, heart failure, cardiac transplantation, valve disease, and genetic cardiomyopathy. |
| spellingShingle | Neubauer, S Cardiac magnetic resonance spectroscopy. |
| title | Cardiac magnetic resonance spectroscopy. |
| title_full | Cardiac magnetic resonance spectroscopy. |
| title_fullStr | Cardiac magnetic resonance spectroscopy. |
| title_full_unstemmed | Cardiac magnetic resonance spectroscopy. |
| title_short | Cardiac magnetic resonance spectroscopy. |
| title_sort | cardiac magnetic resonance spectroscopy |
| work_keys_str_mv | AT neubauers cardiacmagneticresonancespectroscopy |