Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

β-Lactamases enable resistance to almost all β-lactam antibiotics. Pioneering work revealed that acyclic boronic acids can act as 'transition state analogue' inhibitors of nucleophilic serine enzymes, including serine-β-lactamases. Here we report biochemical and biophysical analyses reveal...

Detaylı Bibliyografya
Asıl Yazarlar:	Brem, J, Cain, R, Cahill, S, McDonough, M, Clifton, I, Jiménez-Castellanos, J, Avison, M, Spencer, J, Fishwick, C, Schofield, C
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	Nature Publishing Group 2016

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